Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium
A. I. Sheth, K. Engel, H. Tolison, M. J. Althoff, M. L. Amaya, A. Krug, T. Young, S. Pei, S. B. Patel, M. Minhajuddin, A. Winters, R. Miller, I. Shelton, J. St-Germain, T. Ling, , C. T. Jordan
This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.
bioRxiv · Oct 2, 2023Cancer Biology