Author

S. Pei

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Cancer Biology· 2 Biochemistry· 1 Cell Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 9 Research Focus:drug response / drug discovery· 4 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. E. Gillen· 2 shared A. Krug· 2 shared A. Winters· 2 shared B. M. Stevens· 2 shared C. T. Jordan· 2 shared D. A. Pollyea· 2 shared G. Li· 2 shared H. Tolison· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCancer Biology

A. E. Gillen

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

A. I. Sheth, K. Engel, H. Tolison, M. J. Althoff, M. L. Amaya, A. Krug, T. Young, S. Pei, S. B. Patel, M. Minhajuddin, A. Winters, R. Miller, I. Shelton, J. St-Germain, T. Ling, , C. T. Jordan

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

bioRxiv · Oct 2, 2023Cancer Biology

A novel type of monocytic leukemia stem cell revealed by the clinical use of venetoclax-based therapy

S. Pei, A. E. Gillen, I. T. Shelton, B. M. Stevens, M. Gasparetto, K. Engel, S. Staggs, Y. Wang, W. Showers, A. Inguva, M. L. Amaya, M. Minhajuddin, A. Winters, S. B. Patel, H. Tolison, , C. T. Jordan

The paper identifies a new type of monocytic leukemia stem cell (m-LSC) in AML patients treated with venetoclax, showing its distinct characteristics and clinical relevance.

Cancer Discovery · Sep 6, 2023Peer-reviewedCancer Biology

BacScan: An Unbiased and Genome-Wide Approach to Identify Bacterial Highly Immunogenic Proteins

P. Tao, J. Dong, Q. Zhang, J. Yang, Y. Zhao, Z. Miao, S. Pei, H. Qin, G. Wen, A. Zhang

BacScan identifies highly conserved immunogenic bacterial proteins across serotypes, showing potential for vaccine development.

bioRxiv · Jul 26, 2023Microbiology

Excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics

G. Li, Y. Hu, S. Pei, J. Meng, J. Wang, J. Wang, S. Yue, Z. Wang, S. Wang, X. Liu, Y. Weng, X. Peng, Q. Zhao

This study investigates the excited-state dynamics of the all-trans protonated retinal Schiff base in CRABPII-based rhodopsin mimics using transient absorption and fluorescence spectroscopy, revealing differences in dynamics across mutants and potential applications in bioimaging.

Biophysical Journal · Nov 1, 2022Peer-reviewedBiochemistry

Three amphioxus reference genomes reveal gene and chromosome evolution of chordates

H. Zhen, L. Xu, C. Cai, Y. Zhou, J. Liu, Z. Zhu, W. Kang, D. Chen, S. Pei, T. Xue, W. Cen, C. Shi, X. Wu, Y. Huang, C. Xu, , Q. Zhou

This study presents three amphioxus reference genomes, revealing insights into chordate gene and chromosome evolution, including WGDs, chromatin architecture, and sex chromosome dynamics.

bioRxiv · Jan 4, 2022Evolutionary Biology

An ultrapotent neutralizing bispecific antibody with broad spectrum against SARS-CoV-2 variants

H. Zhang, H. Huang, R. Li, L. Zhang, Z. Wang, J. Li, J. Chen, H. Su, D. Zheng, Z. Su, L. Wang, C. Deng, s. Pei, S. Zhu, C. Li, , X. Huang

This paper develops a bispecific antibody, 2022, that neutralizes SARS-CoV-2 and its variants with high potency, showing strong prophylactic and therapeutic effects in a mouse model.

bioRxiv · Aug 10, 2021 · PreprintMicrobiology

Threshold concentration and random collision determine the growth of the phase-separated huntingtin inclusion from a stable core

S. Pei, T. C. Swayne, J. F. Morris, L. Emtage

The paper investigates how threshold concentration and random collisions drive the growth of phase-separated huntingtin inclusions in yeast.

bioRxiv · Aug 5, 2020Cell Biology

Irradiance modulates thermal niche in a previously undescribed low-light and cold-adapted nano-diatom

J. D. Kling, K. J. Kelly, S. Pei, T. A. Rynearson, D. A. Hutchins

The paper describes a cold-adapted nano-diatom specialized for low-light environments and shows its abundance correlates with winter months in a temperate estuary.

bioRxiv · Jul 21, 2020Microbiology

The unconventional cytoplasmic sensing mechanism for ethanol chemotaxis in Bacillus subtilis

P. Tohidifar, G. A. Bodhankar, S. Pei, C. K. Cassidy, H. E. Walukiewicz, G. W. Orodal, P. J. Stansfeld, C. Rao

This paper identifies an unconventional ethanol sensing mechanism in Bacillus subtilis where ethanol binds the cytoplasmic signaling domain of McpB and the myoglobin-like sensing domain of HemAT.

bioRxiv · Jun 4, 2020Microbiology