Author

T. Young

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2 Microbiology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Assay:bulk RNA-seq· 4 Research Focus:cell type annotation· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

C. Frezza· 4 shared A. Von Kriegsheim· 2 shared D. G. Ryan· 2 shared E. Nikitopoulou· 2 shared M. Yang· 2 shared V. Zecchini· 2 shared A. Basle· 1 shared A. d. M. Pulido· 1 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCancer Biology

C. Frezza

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium

A. I. Sheth, K. Engel, H. Tolison, M. J. Althoff, M. L. Amaya, A. Krug, T. Young, S. Pei, S. B. Patel, M. Minhajuddin, A. Winters, R. Miller, I. Shelton, J. St-Germain, T. Ling, , C. T. Jordan

This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.

bioRxiv · Oct 2, 2023Cancer Biology

Raman micro-spectroscopy reveals the spatial distribution of fumarate in cells and tissues.

M. Kamp, J. Surmacki, M. Segarra Mondejar, T. Young, K. Chrabaszcz, F. Joud, V. Zecchini, A. Speed, C. Frezza, S. Bohndiek

This paper uses Raman micro-spectroscopy to directly detect and map fumarate distribution in living cells and tissues, revealing its compartmentalization and distinguishing Fh1-deficient cells.

bioRxiv · Jul 2, 2023Cell Biology

Microbiome modulates immunotherapy response in cutaneous squamous cell carcinoma

A. Y. Voigt, A. Walter, K. Prieto, A. d. M. Pulido, B. M. B. Bittencourt, T. Young, J. P. Graham, K. Y. Tsai, J. P. Sundberg, J. Oh

This study shows that the skin microbiome affects the response to anti-PD1 immunotherapy in squamous cell carcinoma by using antibiotic-induced microbiome depletion in mice.

bioRxiv · Jan 25, 2023Microbiology

Nitrogen partitioning between branched-chain amino acids and urea cycle enzymes sustains renal cancer progression

M. Sciacovelli, A. Dugourd, L. Valcarcel Jimenez, M. Yang, E. Nikitopoulou, A. S. Costa, L. Tronci, V. Caraffini, P. Rodrigues, C. Schmidt, D. G. Ryan, T. Young, V. Zecchini, S. H. Rossi, C. Massie, , C. Frezza

This study identifies metabolic reprogramming in renal cancer cells, showing how branched-chain amino acid catabolism and urea cycle enzymes support tumor progression and metastasis.

bioRxiv · Sep 17, 2021 · PreprintCancer Biology

Disruption of the TCA cycle reveals an ATF4-dependent integration of redox and amino acid metabolism

D. G. Ryan, M. Yang, H. A. Prag, G. R. Blanco, E. Nikitopoulou, M. Segarra-Mondejar, C. A. Powell, T. Young, N. Burger, J. L. Miljkovic, M. Minczuk, M. P. Murphy, A. Von Kriegsheim, C. Frezza

This study investigates the effects of TCA cycle inhibition on redox and amino acid metabolism, revealing ATF4-dependent metabolic rewiring and distinct responses between FH and SDH inhibition.

bioRxiv · Jul 27, 2021Biochemistry

Acquisition of ionic copper by a bacterial outer membrane protein

S. Bhamidimarri, T. Young, M. Shanmugam, S. Soderholm, A. Basle, D. Bumann, B. van den Berg

This study identifies OprC as a copper transporter in Gram-negative bacteria, showing it binds both reduced and oxidized copper through a unique metal binding site.

bioRxiv · Jun 4, 2020 · PreprintMicrobiology

TFF3 is a ligand for LINGO2 that de-represses EGFR to control disease outcome during colitis and gastrointestinal nematode infection

Y. Ji, Y. Wei, J. Park, L. Y. Hung, T. Young, K. Herbine, T. Oniskey, C. Pastore, W. Nieves, M. Somsouk, D. Herbert

This study identifies TFF3 as a ligand for LINGO2 that de-represses EGFR, influencing disease outcomes in colitis and nematode infection.

bioRxiv · Nov 13, 2018 · PreprintCell Biology

Tumor pre-conditioning of draining lymph node stroma by lactic acid

A. Riedel, J. Swietlik, D. Shorthouse, L. Haas, T. Young, A. S. H. Costa, S. Davidson, L. Pedro, T. Oskarsson, B. A. Hall, C. Frezza, J. Shields

This study identifies lactate as a tumor-derived metabolite that reprograms fibroblastic reticular cells in draining lymph nodes, altering their function and similarity to tumor-associated fibroblasts.

bioRxiv · Oct 12, 2018Cancer Biology