Author

R. Owen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biophysics· 2 Ecology· 1 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:variant calling· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Gerasimova· 2 shared D. Axford· 2 shared F. Lacbawan· 2 shared S. H. Rosenthal· 2 shared A. Acab· 1 shared A. Bhattacharya· 1 shared A. D. Southam· 1 shared A. F. L. Hurlstone· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersMicrobiology

A. Gerasimova

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Mutational order and epistasis determine the consequences of FBXW7 mutations during colorectal cancer evolution

D. K. H. Chan, A. Mandal, Y. Zhou, S. D. Collins, R. Owen, J. Bundred, H. Fuchs, S. James, I. Vendrell, S. Flannery, D. Fawkner-Corbett, J. Househam, T. A. Graham, R. Fischer, A. Simmons, , S. J. A. Buczacki

This study shows that the order of FBXW7 and APC mutations affects colorectal cancer initiation, with FBXW7 mutations before APC preventing cancer-like features.

bioRxiv · Aug 25, 2023 · PreprintCancer Biology

A redox switch allows binding of Fe(II) and Fe(III) ions in the cyanobacterial iron binding protein FutA from Prochlorococcus

R. Bolton, M. M. Machelett, J. Stubbs, D. Axford, N. Caramello, L. Catapano, M. Maly, M. J. Rodrigues, C. Cordery, G. J. Tizzard, F. MacMillan, S. Engilberge, D. von Stetten, T. Tosha, H. Sugimoto, , I. Tews

This paper reveals a redox switch in the cyanobacterial iron binding protein FutA that allows it to bind both Fe(II) and Fe(III) ions through structural analysis.

bioRxiv · May 23, 2023 · PreprintBiophysics

Modelling the spread of resistance to Varroa in Australian feral honeybee populations

R. Owen, J.-P. Scheerlinck, M. Stevenson

The paper models how introducing Varroa-resistant queens into managed honeybee populations affects the recovery time of feral populations after a Varroa incursion.

bioRxiv · Feb 10, 2022 · PreprintEvolutionary Biology

Identification of eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens

S. H. Rosenthal, R. M. Kagan, A. Gerasimova, B. Anderson, D. grover, M. Hua, R. Owen, F. Lacbawan

The paper identifies eight SARS-CoV-2 ORF7a deletion variants in 2,726 clinical specimens collected in March 2020.

bioRxiv · Dec 10, 2020 · PreprintMicrobiology

Analytical validation and performance characteristics of a 48-gene next-generation sequencing panel for detecting potentially actionable genomic alterations in myeloid neoplasms

S. H. Rosenthal, A. Gerasimova, C. Ma, H.-R. Li, A. Grupe, H. Chong, A. Acab, A. Smolgovsky, R. Owen, C. Elzinga, R. Chen, D. Sugganth, T. Freitas, J. Graham, K. Champion, , F. Lacbawan

The paper validates a 48-gene NGS panel for detecting actionable genomic mutations in myeloid neoplasms, showing high sensitivity and specificity.

bioRxiv · Nov 30, 2020Cancer Biology

DGAT1 is a lipid metabolism oncoprotein that enables cancer cells to accumulate fatty acid while avoiding lipotoxicity

D. J. Wilcock, A. P. Badrock, R. Owen, M. Guerin, A. D. Southam, H. Johnston, S. Ogden, P. Fullwood, J. Watson, H. Ferguson, J. Haworth, D. A. Richardson, G. R. Lloyd, A. Jankevics, W. B. Dunn, , A. F. L. Hurlstone

This study identifies DGAT1 as an oncoprotein that enables cancer cells to accumulate fatty acids while avoiding lipotoxicity, promoting melanoma formation.

bioRxiv · Jun 23, 2020 · PreprintCancer Biology

Direct measurement of X-ray induced heating of microcrystals

A. Warren, D. Axford, R. Owen

The paper quantifies X-ray induced heating of microcrystals by measuring temperature-dependent shifts in X-ray induced fluorescence from ruby crystals.

Journal of Synchrotron Radiation · Jul 1, 2019Peer-reviewedBiophysics

Subtle, seasonal and potentially important: Are phytotoxic foliage leachates overlooked in plant invasion studies?

G. Jones, M. Tomlinson, R. Owen, J. Scullion, A. Winters, T. Jenkins, J. Ratcliffe, D. Gwynn-Jones

This study investigates seasonal variation in phytotoxic compounds from Rhododendron ponticum leaves and their impact on seed germination.

bioRxiv · Mar 5, 2019 · PreprintEcology