Cancer BiologybioRxiv
Targeting Acute Myeloid Leukemia Stem Cells Through Perturbation of Mitochondrial Calcium
A. I. Sheth, K. Engel, H. Tolison…·C. T. Jordan
This study identifies mitochondrial calcium utilization as a metabolic requirement of venetoclax-resistant acute myeloid leukemia stem cells and shows that targeting mitochondrial calcium uptake can eradicate these cells.
DOI 10.1158/2159-8290.cd-23-1145