Author

A. Zakharchenko

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:rat· 1

Frequent Co-Authors

G. Ferrari· 3 shared S. Keeney· 3 shared A. Krieger· 2 shared C. Rock· 2 shared H. Takano· 2 shared R. J. Levy· 2 shared A. Frasca· 1 shared A. M. Krieger· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiochemistry

G. Ferrari

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3 papers

Recent·Most cited

Inhibition of advanced glycation end product formation and serum protein infiltration in bioprosthetic heart valve leaflets: Investigations of anti-glycation agents.

A. Zakharchenko, C. Rock, T. Thomas, S. Keeney, E. Hall, H. Takano, A. Krieger, G. Ferrari, R. Levy

This study investigates anti-AGE agents' effects on AGE and serum protein infiltration in bioprosthetic heart valves using in vitro and in vivo models, finding that PYR significantly inhibits AGE and serum albumin accumulation.

bioRxiv · Feb 28, 2022 · PreprintBiochemistry

Deterioration of Glutaraldehyde Crosslinked Heterograft Biomaterials due to Advanced Glycation End Product Formation and Serum Albumin Infiltration

C. A. Rock, S. Keeney, A. Zakharchenko, H. Takano, D. A. Spiegel, A. M. Krieger, G. Ferrari, R. J. Levy

This study investigates how AGE formation and serum albumin infiltration degrade glutaraldehyde crosslinked biomaterials, leading to structural and mechanical deterioration in bioprosthetic heart valves.

bioRxiv · May 28, 2020 · PreprintBiophysics

Glycation and Serum Albumin Infiltration Contribute to the Structural Degeneration of Bioprosthetic Heart Valves

A. Frasca, Y. Xue, A. P. Kossar, S. Keeney, C. Rock, A. Zakharchenko, M. Streeter, R. C. Gorman, J. B. Grau, I. George, J. E. Bavaria, A. Krieger, D. Spiegel, R. J. Levy, G. Ferrari

This study shows glycation and serum albumin infiltration contribute to structural degeneration of bioprosthetic heart valves through mechanisms observed in both clinical samples and in vitro models.

bioRxiv · Feb 14, 2020Bioengineering