Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing
A. Maynard, C. E. McCoach, J. K. Rotow, L. Harris, F. Haderk, L. D. Kerr, E. A. Yu, E. L. Schenk, W. Tan, A. Zee, M. Tan, P. Gui, T. Lea, W. Wu, A. Urisman, , T. G. Bivona
This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.
bioRxiv · Dec 8, 2019 · PreprintCancer Biology