A. Urisman

The deubiquitinase USP9X regulates RIT1 protein abundance and oncogenic phenotypes

This study shows that USP9X stabilizes RIT1 protein and that its depletion reduces RIT1 abundance and sensitizes cells to EGFR inhibitors.

Data-Independent Acquisition and Quantification of Extracellular Matrix from Human Lung in Chronic Inflammation-Associated Carcinomas

The paper develops a proteomic pipeline to analyze ECM remodeling in lung squamous cell carcinoma, identifying 529 differentially expressed proteins and potential biomarkers.

PKC-alpha promotes phosphorylation of KRAS suppressing its oncogenic properties

This study identifies PKC-alpha as a suppressor of KRAS oncogenic properties through phosphorylation, altering the KRAS-CaM signaling axis in KRAS mutant tumor cells.

Deep tissue infection by an invasive human fungal pathogen requires novel lipid-based suppression of the IL-17 response

This study identifies a mechanism by which Candida albicans suppresses the host IL-17 response through lipid-mediated immunosuppression, leading to invasive disease.

The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppression

This study shows that RIT1, a Ras GTPase, suppresses the spindle assembly checkpoint, leading to mitotic errors and chromosome segregation defects.

Deficiency of the splicing factor RBM10 limits EGFR inhibitor response in EGFR mutant lung cancer

This study shows that RBM10 deficiency reduces EGFR inhibitor efficacy in EGFR mutant lung cancer by altering Bcl-x splicing and apoptosis, and that co-inhibiting Bcl-xL can overcome this resistance.

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.

Targeted phosphoproteomics of the Ras signaling network reveal regulatory mechanisms mediated by oncogenic KRAS

This study uses targeted phosphoproteomics to analyze KRAS signaling network regulation in lung cancer cells, identifying unique phosphorylation changes and their roles in transcriptional silencing.