Author

E. L. Schenk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 4

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

A. M. Johnson· 3 shared E. T. Clambey· 3 shared L. E. Heasley· 2 shared R. A. Nemenoff· 2 shared A. Gupta· 1 shared A. J. Neuwelt· 1 shared A. Maynard· 1 shared A. Navarro· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

A. M. Johnson

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Adaptive immunity is required for durable responses to alectinib in murine models of EML4-ALK lung cancer

E. K. Kleczko, T. K. Hinz, T. T. Nguyen, N. J. Gurule, A. Navarro, A. T. Le, A. M. Johnson, J. Kwak, D. I. Polhac, E. T. Clambey, M. C. Weiser-Evans, T. Patil, E. L. Schenk, L. E. Heasley, R. A. Nemenoff

This paper shows that adaptive immunity enhances the durability of alectinib response in EML4-ALK lung cancer models, with CD8+ T cells playing a key role.

bioRxiv · Apr 14, 2022 · PreprintCancer Biology

Cancer cell-specific MHCII expression as a determinant of the immune infiltrate organization and function in the non-small cell lung cancer tumor microenvironment

A. M. Johnson, J. M. Boland, J. L. Wrobel, E. K. Klezcko, M. L. Weisner-Evans, L. Heasley, E. T. Clambey, R. L. Nemenoff, E. L. Schenk

The paper examines MHCII expression in NSCLC tumor microenvironment and finds it correlates with immune infiltration, spatial proximity, and improved survival.

bioRxiv · Feb 24, 2021Cancer Biology

Cancer Cell Intrinsic Expression of MHCII Regulates the Immune Microenvironment and Response to Anti-PD-1 Therapy in Lung Adenocarcinoma

A. M. Johnson, B. L. Bullock, A. J. Neuwelt, J. M. Poczobutt, R. E. Kaspar, H. Y. Li, J. W. Kwak, K. Hopp, M. C. M. Weiser-Evans, L. E. Heasley, E. L. Schenk, E. T. Clambey, R. A. Nemenoff

This study shows that cancer cell expression of MHCII affects T cell infiltration and response to anti-PD-1 therapy in lung adenocarcinoma.

bioRxiv · Jan 9, 2020 · PreprintCancer Biology

Heterogeneity and targeted therapy-induced adaptations in lung cancer revealed by longitudinal single-cell RNA sequencing

A. Maynard, C. E. McCoach, J. K. Rotow, L. Harris, F. Haderk, L. D. Kerr, E. A. Yu, E. L. Schenk, W. Tan, A. Zee, M. Tan, P. Gui, T. Lea, W. Wu, A. Urisman, , T. G. Bivona

This study uses longitudinal single-cell RNA sequencing to reveal therapy-induced adaptations in lung cancer, identifying cell state transitions and pathways associated with treatment response and resistance.

bioRxiv · Dec 8, 2019 · PreprintCancer Biology