Author

A.-M. Schaffer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

G. J. Fiala· 2 shared L. A. Herr· 2 shared S. Minguet· 2 shared A.-S. Mägdefrau· 1 shared C. Kosan· 1 shared E. Miho· 1 shared E. Natali· 1 shared E.-M. Piskor· 1 shared

Activity by Year

2022-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

G. J. Fiala

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

R. Winkler, A.-S. Mägdefrau, E.-M. Piskor, M. Kleemann, M. Beyer, K. Linke, L. Hansen, A.-M. Schaffer, M. E. Hoffmann, S. Poepsel, F. Heyd, P. Beli, T. Möröy, S. Mahboobi, O. H. Krämer, C. Kosan

This study shows that inhibiting HDAC6 with Marbostat-100 reduces MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced B-cell lymphoma.

Oncogene · Sep 6, 2022Peer-reviewedCancer Biology

Kidins220 promotes thymic iNKT cell development by reducing TCR signals, but enhances TCR signals in splenic iNKT cells

L. A. Herr, G. J. Fiala, A.-M. Schaffer, K. Raute, R. M.-H. Velasco Cardenas, J. F. Hummel, K. Ebert, Y. Tanriver, S. Minguet, W. W. Schamel

This study shows Kidins220 modulates TCR signaling in thymic and splenic iNKT cells, promoting development in the thymus by reducing TCR signals but enhancing TCR signals in the periphery.

bioRxiv · Apr 5, 2022 · PreprintImmunology

Kidins220 regulates the development of B cells bearing the {lambda} light chain

A.-M. Schaffer, G. J. Fiala, M. Hils, E. Natali, L. Babrak, L. A. Herr, M. Rizzi, E. Miho, W. Schamel, S. Minguet

This study shows Kidins220 regulates λLC B cell development by supporting precursor survival and optimizing pre-BCR/BCR signaling for λLC locus opening and recombination.

bioRxiv · Apr 4, 2022Immunology