Author

L. Hansen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Ecology· 1 Microbiology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Drake· 1 shared A. Gerold· 1 shared A. Gobbi· 1 shared A. Kannan· 1 shared A. Sharma· 1 shared A. Tzou· 1 shared A. V. Belsare· 1 shared A.-M. Schaffer· 1 shared

Activity by Year

2018-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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1 shared paperCancer Biology

A. Drake

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Context-dependence of T-loop mediated long-range RNA tertiary interactions

L. Hansen, O. A. Kletzien, M. Urquijo, L. T. Schwanz, R. T. Batey

The paper uses a genetic screen and bioinformatics to study context-dependent T-loop receptor interactions in riboswitches, finding restricted functional sequence space and distinct nucleobase-mediated interactions.

bioRxiv · Dec 26, 2022Biochemistry

Targeting the MYC interaction network in B-cell lymphoma via histone deacetylase 6 inhibition

R. Winkler, A.-S. Mägdefrau, E.-M. Piskor, M. Kleemann, M. Beyer, K. Linke, L. Hansen, A.-M. Schaffer, M. E. Hoffmann, S. Poepsel, F. Heyd, P. Beli, T. Möröy, S. Mahboobi, O. H. Krämer, C. Kosan

This study shows that inhibiting HDAC6 with Marbostat-100 reduces MYC levels and prevents lymphomagenesis in a mouse model of MYC-induced B-cell lymphoma.

Oncogene · Sep 6, 2022Peer-reviewedCancer Biology

An agent-based framework for improving wildlife disease surveillance: A case study of chronic wasting disease in Missouri white-tailed deer

A. V. Belsare, M. E. Gompper, B. Keller, J. Sumners, L. Hansen, J. Millspaugh

The paper develops an agent-based framework to improve wildlife disease surveillance by simulating disease prevalence and sampling in Missouri white-tailed deer, showing overestimation of CWD detection confidence under unrealistic assumptions.

bioRxiv · Oct 26, 2019Ecology

Machine learning enables detection of early-stage colorectal cancer by whole-genome sequencing of plasma cell-free DNA

N. Wan, D. Weinberg, T.-y. Liu, K. Niehaus, D. Delubac, A. Kannan, B. White, E. Ariazi, M. Bailey, M. Bertin, N. Boley, D. Bowen, J. Cregg, A. Drake, R. Ennis, , I. S. Haque

This paper uses machine learning on whole-genome sequencing of plasma cell-free DNA to detect early-stage colorectal cancer with high sensitivity and specificity.

bioRxiv · Nov 24, 2018Cancer Biology

Critical Limb Ischemia Induces Remodeling of Skeletal Muscle Motor Unit and Myonuclear- and Mitochondrial-Domains

M. Mohiuddin, N. H. Lee, J. Y. Moon, W. M. Han, S. E. Anderson, J. J. Choi, S. Nakhai, T. Tran, B. Aliya, D. Y. Kim, A. Gerold, L. Hansen, W. R. Taylor, Y. C. Jang

This study investigates how critical limb ischemia affects skeletal muscle by increasing myonuclear number and mitochondrial content per myonucleus in mice.

bioRxiv · Sep 25, 2018Physiology

Quantitative and qualitative evaluation of the impact of the G2 enhancer, bead sizes and lysing tubes on the bacterial community composition during DNA extraction from recalcitrant soil core samples based on community sequencing and qPCR

A. Gobbi, R. G. Santini, E. Filippi, L. Ellegaard-Jensen, C. S. Jacobsen, L. Hansen

bioRxiv · Jul 9, 2018Microbiology

MTAP loss correlates with an immunosuppressive profile in GBM and its substrate MTA stimulates alternative macrophage polarization

L. Hansen, R. Yang, K. I. Woroniecka, L. Chen, H. Yan, Y. He

The paper shows MTAP loss in GBM correlates with an immunosuppressive profile by increasing M2 macrophages and that MTA, a byproduct of MTAP loss, promotes this effect through the A2B receptor.

bioRxiv · May 24, 2018Cancer Biology