Author

A.-S. Jemth

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:proteomics· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

T. Helleday· 4 shared T. Koolmeister· 3 shared E. J. Homan· 2 shared E. R. Scaletti· 2 shared I. Almlof· 2 shared M. Michel· 2 shared M. Scobie· 2 shared O. Loseva· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersBiochemistry

T. Helleday

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Author profile →

4 papers

Recent·Most cited

Kinetic and structural characterization of human NUDIX hydrolase NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

E. R. Scaletti, J. E. Unterlass, I. Almlof, T. Koolmeister, K. S. Vallin, D. Kapsitidou, T. Helleday, P. Stenmark, A.-S. Jemth

This study identifies NUDT15 and NUDT18 as human enzymes that hydrolyze isoprene pyrophosphates, with NUDT18 showing the highest catalytic efficiency for geranyl pyrophosphate.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

S. M. Zhang, C. B. Paulin, M. Michel, P. Marttila, M. Yagüe-Capilla, H. C. Bwanika, H. Shu, R. Papagudi Vekatram, E. Wiita, A.-S. Jemth, I. Almlöf, O. Loseva, F. Ortis, C. Dirks, T. Koolmeister, , S. G. Rudd

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

bioRxiv · Jan 17, 2023 · PreprintBiochemistry

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

A.-S. Jemth, E. R. Scaletti, E. J. Homan, P. Stenmark, T. Helleday, M. Michel

This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.

bioRxiv · Nov 16, 2021 · PreprintBiochemistry

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

bioRxiv · Sep 5, 2019 · PreprintCancer Biology