Author

P. Stenmark

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 3 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein design· 1 Research Focus:protein folding & dynamics· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

T. Helleday· 3 shared A.-S. Jemth· 2 shared E. R. Scaletti· 2 shared I. Almlof· 2 shared M. Martinez-Carranza· 2 shared A. Rajavel· 1 shared A. Rasti· 1 shared A. Throup· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBiochemistry

T. Helleday

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Author profile →

5 papers

Recent·Most cited

Kinetic and structural characterization of human NUDIX hydrolase NUDT15 and NUDT18 as catalysts of isoprene pyrophosphate hydrolysis

E. R. Scaletti, J. E. Unterlass, I. Almlof, T. Koolmeister, K. S. Vallin, D. Kapsitidou, T. Helleday, P. Stenmark, A.-S. Jemth

This study identifies NUDT15 and NUDT18 as human enzymes that hydrolyze isoprene pyrophosphates, with NUDT18 showing the highest catalytic efficiency for geranyl pyrophosphate.

bioRxiv · Nov 29, 2023 · PreprintBiochemistry

Structure and activity of botulinum neurotoxin X

M. Martinez-Carranza, J. Skerlova, P.-G. Lee, J. Zhang, D. Burgin, M. Elliott, J. Philippe, S. Donald, F. Hornby, L. Henriksson, G. Masuyer, M. Beard, M. Dong, P. Stenmark

The paper presents the cryo-EM structure of BoNT/X-NTNH/X complex and shows its stability and low potency due to weak receptor-binding properties.

bioRxiv · Jan 11, 2023 · PreprintBiochemistry

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

N. C. K. Valerie, K. Sanjiv, O. Mortusewicz, S. M. Zhang, S. Alam, M. J. Pires, H. Stigsdotter, A. Rasti, M.-F. Langelier, D. Rehling, A. Throup, M. Desroses, J. Onireti, P. Wakchaure, I. Almlof, , M. Altun

CeTEAM evaluates drug-target interactions and phenotypic responses using biosensors, revealing how drug binding affects cellular activities and metabolism.

bioRxiv · Sep 19, 2022Biochemistry

NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir

A.-S. Jemth, E. R. Scaletti, E. J. Homan, P. Stenmark, T. Helleday, M. Michel

This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.

bioRxiv · Nov 16, 2021 · PreprintBiochemistry

A rationally designed and highly versatile epitope tag for nanobody-based purification, detection and manipulation of proteins

H. Goetzke, M. Kilisch, M. Martinez-Carranza, S. Sograte-Idrissi, A. Rajavel, T. Schlichthaerle, N. Engels, R. Jungmann, P. Stenmark, F. Opazo, S. Frey

The paper introduces the ALFA-tag, a versatile epitope tag that outperforms existing tags and enables multiple applications in protein detection, purification, and manipulation.

bioRxiv · Jun 7, 2019Biochemistry