Author

J. Bostrom

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:zebrafish· 1

Frequent Co-Authors

I. Almlof· 2 shared K. Sanjiv· 2 shared M. Altun· 2 shared O. Mortusewicz· 2 shared P. Wakchaure· 2 shared T. Helleday· 2 shared A. Hagenkort· 1 shared A. Harisankar· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersBiochemistry

I. Almlof

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Coupling cellular drug-target engagement to downstream pharmacology with CeTEAM

N. C. K. Valerie, K. Sanjiv, O. Mortusewicz, S. M. Zhang, S. Alam, M. J. Pires, H. Stigsdotter, A. Rasti, M.-F. Langelier, D. Rehling, A. Throup, M. Desroses, J. Onireti, P. Wakchaure, I. Almlof, , M. Altun

CeTEAM evaluates drug-target interactions and phenotypic responses using biosensors, revealing how drug binding affects cellular activities and metabolism.

bioRxiv · Sep 19, 2022Biochemistry

Identification of GTF2IRD1 as a novel transcription factor essential for acute myeloid leukemia

Y. Heshmati, G. Turkoz, J. Zawacka, M. Dimitriou, A. Harisankar, J. Bostrom, H. Cai, N. Kadri, M. Altun, H. Qian, J. Walfridsson

This study identifies GTF2IRD1 as a novel transcription factor essential for AML cell survival and disease progression, with potential therapeutic implications.

bioRxiv · Aug 9, 2022 · PreprintCancer Biology

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

H. Gad, O. Mortusewicz, S. G. Rudd, A. Stolz, N. Amaral, L. Brautigam, L. Pudelko, K. Sanjiv, C. Kalderen, A.-S. Jemth, I. Almlof, T. Visnes, N. Schultz, J. Bostrom, J. M. Calderon Montano, , T. Helleday

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

bioRxiv · Sep 5, 2019 · PreprintCancer Biology