Author

H. Shu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Biochemistry· 1 Biophysics· 1 Ecology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 3 Assay:proteomics· 3 Assay:ChIP-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:plant (other)· 2 Assay:ATAC-seq· 1

Frequent Co-Authors

S. Dong· 3 shared H. Chen· 2 shared H. Wang· 2 shared J. Ma· 2 shared J. Wang· 2 shared X. Lin· 2 shared Y. Fang· 2 shared Y. Wang· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersMicrobiology

S. Dong

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Biogenic phosphonate utilization by globally distributed diatom Thalassiosira

H. Shu, Y. Shen, H. Wang, X. Sun, J. Ma, X. Lin

This study shows that the diatom Thalassiosira pseudonana can use biogenic phosphonates as a phosphorus source, affecting its elemental stoichiometry and growth under phosphorus starvation.

bioRxiv · Aug 2, 2023 · PreprintEcology

Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel

S. M. Zhang, C. B. Paulin, M. Michel, P. Marttila, M. Yagüe-Capilla, H. C. Bwanika, H. Shu, R. Papagudi Vekatram, E. Wiita, A.-S. Jemth, I. Almlöf, O. Loseva, F. Ortis, C. Dirks, T. Koolmeister, , S. G. Rudd

This paper identifies and evaluates small-molecule inhibitors of SAMHD1 through a comprehensive screening pipeline, revealing a novel mode of inhibition and potential therapeutic applications.

bioRxiv · Jan 17, 2023 · PreprintBiochemistry

Genome-wide analyses of histone modifications and chromatin accessibility reveal the distinct genomic compartments in the Irish potato famine pathogen Phytophthora infestans

H. Chen, H. Shu, Y. Fang, W. Song, Z. Li, Y. Fang, Y. Wang, S. Dong

The paper analyzes histone modifications and chromatin accessibility in Phytophthora infestans to reveal distinct genomic compartments and their association with virulence factor genes.

bioRxiv · Feb 18, 2022 · PreprintMicrobiology

Comparative transcriptomics unveil distinctive metabolic pathway of phosphonate utilization by diatom Phaeodactylum tricornutum

H. Shu, Y. You, H. Wang, J. Wang, L. Li, X. Lin, J. Ma

This study identifies a unique phosphonate utilization mechanism in diatom Phaeodactylum tricornutum involving uptake via clathrin-mediated endocytosis and incorporation into membrane phospholipids.

bioRxiv · Feb 9, 2022 · PreprintMicrobiology

Understanding the phase separation characteristics of nucleocapsid protein provides a new therapeutic opportunity against SARS-CoV-2

D. Zhao, W. Xu, X. Zhang, X. Wang, E. Yuan, Y. Xiong, S. Wu, S. Li, N. Wu, T. Tian, X. Feng, H. Shu, P. Lang, X. Shen, H. Li, , J. Zeng

This study identifies that SARS-CoV-2 nucleocapsid protein undergoes phase separation, which can be modulated by small molecules, offering new therapeutic strategies against COVID-19.

Protein & Cell · Mar 26, 2021Peer-reviewedBiophysics

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

Y. Fang, M. A. Coelho, H. Shu, K. Schotanus, B. C. Thimmappa, V. Yadav, H. Chen, E. P. Malc, J. Wang, P. Mieczkowski, B. Kronmiller, B. M. Tyler, K. Sanyal, S. Dong, M. Nowrousian, J. Heitman

This paper identifies centromeres in Phytophthora sojae using long-read sequencing and ChIP-seq, revealing transposon-rich, heterochromatic regions distinct from other SAR supergroup organisms.

bioRxiv · Jan 30, 2020Microbiology

Cleavage of a pathogen apoplastic protein by plant subtilases activates immunity

S. Wang, R. Xing, Y. Wang, H. Shu, S. Fu, J. Paulus, M. Schuster, D. Saunders, J. Win, V. Vleeshouwers, X. Zheng, R. A. L. van der Hoorn, S. Kamoun, S. Dong

This study shows that cleavage of a pathogen protein by plant proteases activates immunity, while pathogens counteract this with inhibitors.

bioRxiv · Dec 16, 2019Plant Biology