N. Schultz

Sharing Data from the Human Tumor Atlas Network through Standards, Infrastructure, and Community Engagement

The paper describes how the Human Tumor Atlas Network shares data through standards, infrastructure, and community engagement, making datasets accessible via multiple platforms.

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Analysis of evolutionary dynamics and clonal architecture in prostate cancer

This study analyzes prostate cancer clonal architecture and evolutionary dynamics in 845 tumors, finding that Black patients have more monoclonal tumors but higher recurrence rates, and identifies new mutational signatures linked to subclones.

Distinct tumor architectures for metastatic colonization of the brain

This study compares the brain metastasis colonization strategies of triple-negative breast cancer and HER2+ breast cancer, revealing distinct tumor architectures and stromal interactions.

Integrative analysis of the MD Anderson Prostate Cancer Patient-Derived Xenograft Series (MDA PCa PDX)

The paper characterizes the genomic and transcriptomic landscape of MDA PCa PDX models and develops an organoid platform to study prostate cancer heterogeneity and resistance.

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking CLU+ CAF expression with HSF1 signaling

This study shows BRCA mutations in pancreatic cancer alter CAF subtypes, specifically increasing CLU+ CAFs, and links this to HSF1 signaling.

Genomic and Metabolic Hallmarks of SDH- and FH-Deficient Renal Cell Carcinomas

This study compares the genomic and metabolic features of SDH- and FH-deficient renal cell carcinomas, identifying distinct genetic and metabolic abnormalities.

MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

This study identifies MTH1's role in mitosis and shows that potent MTH1 inhibitors cause mitotic arrest by disrupting tubulin polymerization and suppressing ROS.

Lower dormancy with rapid germination is an important strategy for seeds in an arid zone with unpredictable rainfall

This study examines seed germination strategies of eight arid zone woody plant species, finding that most have non-dormant, rapidly germinating seeds, while some exhibit dormancy to cope with unpredictable rainfall.

Integration and analysis of CPTAC proteomics data in the context of cancer genomics in the cBioPortal

The paper integrates CPTAC proteomics data into cBioPortal to enable integrative analysis with genomics and clinical data from the same tumors.