BiochemistrybioRxivPreprint
NUDT18 catalyzes the hydrolysis of active metabolites of the antivirals Remdesivir, Ribavirin and Molnupiravir
A.-S. Jemth, E. R. Scaletti, E. J. Homan…·M. Michel
This study identifies NUDT18 as a hydrolase that hydrolyzes triphosphates of antivirals like Remdesivir, Molnupiravir, and Ribavirin, potentially reducing their antiviral efficacy.
DOI 10.1101/2021.11.16.468802