Aakash Chandramouli

This study identifies lipoprotein lipase (LPL) as a neutral cholesteryl ester hydrolase in mammals through biochemical and pharmacological analyses.

This study uses three orthogonal chemical proteomic strategies to identify 495 cholesteryl ester-associated proteins in mammalian cells, revealing their functional and disease relevance.

This study shows LSD1 regulates host alpha-ketoglutarate levels, modulating lipid peroxidation and mycobacterial survival during tuberculosis infection.

This study identifies a metabolic hierarchy in Caulobacter crescentus that coordinates cell cycle transitions and morphogenesis through redox dynamics.

The paper identifies shared and sex-specific lipidomic changes in brain and plasma of Parkinson's disease models and patients, showing peripheral lipid signatures reflect CNS pathology.

This study identifies PE11 as a factor that promotes Mtb persistence by inhibiting autophagy and lysosomal biogenesis through the FLCN-lactate-TFEB signaling axis, with lactate shown to enhance bacterial clearance.

This study identifies ACSL4 as a driver of TNBC metastasis by enhancing histone acetylation and SNAIL expression through metabolic and epigenetic mechanisms.

The paper develops a reverse-phase LC-MS method to profile cholesterol and cholesteryl esters in mammalian cells and tissues, revealing their monounsaturated and polyunsaturated variants.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.