Binayak Sarkar

This study combines a homogenous KIM-1-targeted ADC with sunitinib to treat RCC, showing synergistic antitumor efficacy in a mouse model.

This study identifies IL-17 and COX2 as negative regulators of protective immunity in tuberculosis, showing that Ly6G+ granulocytes are a major source of IL-17 and their inhibition reduces bacterial burden and pathology.

This paper identifies a Mycobacterium tuberculosis secreted protein that disrupts host snRNP biogenesis, altering RNA splicing and contributing to pathogenesis.

This study shows Mtb induces PPARγ in hepatocytes to create lipid droplets and drug-tolerant environments, contributing to systemic pathogenicity and metabolic impairments during TB infection.