Recombinant SARS-CoV-2 lacking initiating and internal methionine codons within ORF10 is attenuated in vivo
Shichun Gu, Eleanor G. Bentley, Rachel I Milligan…·David A. Matthews
This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.