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Alec L. Lourenço

California Institute of Technology

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Bioengineering· 1

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Assay:protein structure· 1 Research Focus:sequence-to-function modeling· 1 Approach:transformer / foundation model· 1

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Arjuna M. SubramanianiD· 1 shared Matt Thomson· 1 shared Shichen LiuiD· 1 shared Sonia C. YuaniD· 1 shared Ting-Yu WangiD· 1 shared Tsui‐Fen ChouiD· 1 shared Zachary A. MartineziD· 1 shared

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Arjuna M. SubramanianORCID

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Recent·Most cited

BioengineeringbioRxivPreprintDec 22, 2023

Unexplored regions of the protein sequence-structure map revealed at scale by a library of foldtuned language models

Arjuna M. Subramanian, Zachary A. Martinez, Alec L. Lourenço…·Matt Thomson

This paper introduces foldtuning, a method to generate novel protein sequences with target structures, bypassing evolutionary barriers and enabling synthetic biology applications.

11 citations

protein sequenceprotein structure

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