Tsui‐Fen Chou

This paper introduces SLIM, a method for unbiased genome reduction in diverse bacteria, and demonstrates its application in Escherichia coli and other species.

The paper identifies FAM136A as a chaperone essential for mitochondrial membrane protein biogenesis, specifically for VDAC paralogs and some electron transport chain subunits.

This study identifies ENAH as an interactor of the HTT1a PRD and shows that EVH1 domain binding modulates HTT1a aggregation and fibril remodeling.

This study identifies a bacterial antiphage defense system combining Ago and SLFN domains, showing how ATP-driven tetramerization and RNA-guided filament assembly regulate nuclease activity.

This study identifies stk32a as a conserved sleep regulator that links neuropeptidergic signaling to sleep homeostasis by suppressing sensory and motor systems in zebrafish and mice.

The paper identifies TXNDC15 as a regulator of ER membrane protein quality control, showing it modulates MARCHF6 to prevent degradation of critical ciliary proteins, thereby affecting ciliogenesis.

The paper shows proteomic asymmetry in mouse and human embryos that influences lineage segregation.

This study investigates how the Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links using Xenopus egg extracts.

The paper identifies cold-sensitive protein conformational changes across the proteome using mass spectrometry in E. coli.

This study models Parkinson's disease in spiny mice, showing they exhibit key disease features like behavioral impairments, neuronal degeneration, and proteomic changes similar to PD.

This study introduces PhaseID, a method to identify protein components in LLPS condensates formed by IDRs, revealing how LLPS tunes interaction selectivity and enables new cellular functions.

This study shows that the gut microbiome increases mitochondrial respiration and oxidative stress in the brain of a Parkinson's disease mouse model, worsening motor symptoms.

This study shows ATM kinase promotes reversed fork resection during ICL repair, dependent on EXO1 and DNA2 nucleases, and reveals PP2A's role in regulating this process.

The paper identifies regulatory elements and transcription factors in E. coli genes across diverse environments using experimental and computational methods.

This paper uses subcellular proteomics to show that glycolytic and gluconeogenic enzymes are mosaically localized in Paramecium tetraurelia, with some enzymes in mitochondria and others in the cytosol, suggesting a preference for gluconeogenesis.

This study optimizes the One-Pot PURE system by addressing expression instability and proteolysis in E. coli strains, improving protein production efficiency.

This study investigates the distinct roles of VDAC1, VDAC2, and VDAC3 in mitochondrial respiration and cancer cell metabolism through isoform-specific knockouts in HeLa cells.

The paper applies molecularly-guided single-cell spatial proteomics to study proteomic differences in healthy and diseased mammalian brains, revealing insights into Parkinson's disease.

The paper shows that reducing Cofilin dosage in Drosophila embryos enhances stress adaptation and thermotolerance by priming stress response pathways.

This study identifies NAMPT's phosphoribosyl-hydrolase activity as a mechanism to restrict HSV-1 infection by de-phosphoribosylating viral structural proteins.

The paper studies the biogenesis of ER membrane proteins, identifying the EMC and BOS complex as key players and proposing a model for coordinated insertion.

The paper uses single-tissue proteomics in C. elegans to identify proteins in intestinal lysosome-related organelles, revealing novel components and interorgan protein transport.

This paper introduces foldtuning, a method to generate novel protein sequences with target structures, bypassing evolutionary barriers and enabling synthetic biology applications.

The paper identifies novel VCP variants causing a childhood-onset neurodevelopmental disorder through exome sequencing and functional analysis.

This study uses cryo-electron tomography to reveal the structure of Anabaena flos-aquae gas vesicles, showing how GvpA subunits form the shell and how GvpC provides structural reinforcement.

The paper identifies new interactors of LINKIN (ITFG1) and shows their role in cell migration and tissue integrity in C. elegans and human breast cancer cells.

This study investigates DNAJB6 isoform-specific knockdown as a potential therapy for LGMDD1, showing that reducing DNAJB6b levels in a mouse model corrected proteomic disease signatures.

This study shows that rhNAGLU-IGF2 treatment improves disease markers, behavior, and survival in Sanfilippo B mice and dogs.

This study shows that inhibiting VCP activity rescues degenerating P23H rod cells and improves their function in retinal models of adRP.