Cancer BiologybioRxivPreprint
SMAD4 loss drives cancer chromosomal instability through transcription-replication conflict-induced replication stress
Atmika Paul, Gargee Joshi, Philipp Jungk…·Holger Bastians
This study shows SMAD4 loss causes cancer chromosomal instability by inducing replication stress through transcription-replication conflicts via BMP signaling.
DOI 10.64898/2025.12.17.694873