Holger Bastians

This study shows SMAD4 loss causes cancer chromosomal instability by inducing replication stress through transcription-replication conflicts via BMP signaling.

This study shows Wnt10b signaling prevents replication stress-induced chromosomal instability in cancer cells by suppressing microtubule dynamics and chromosome missegregation.

This study shows that BTRR complex deficiency increases genomic instability through copy number alterations, enriched at fragile sites, using CRISPR-edited iPSC models.

The paper identifies a signalling rheostat involving WNT, BMP, and FGF that modulates DNA replication stress and chromosome segregation fidelity during lineage specification and neurogenesis.