Author

B. A. Colson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Assay:fluorescence / live-cell microscopy· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

T. A. Bunch· 3 shared V. C. Lepak· 3 shared D. D. Thomas· 2 shared P. Guhathakurta· 2 shared A. L. Carter· 1 shared A. R. Thompson· 1 shared A. Thompson· 1 shared A. Wilson· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersBiophysics

T. A. Bunch

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Drug discovery for heart failure targeting myosin-binding protein C

T. A. Bunch, P. Guhathakurta, A. Thompson, V. C. Lepak, A. L. Carter, J. J. Thomas, D. D. D. Thomas, B. A. Colson

This study identifies small molecules that modulate cMyBP-C interactions with actin or myosin, aiming to develop therapies for heart failure.

bioRxiv · Apr 3, 2023Biophysics

N-terminal cardiac myosin-binding protein C interactions with myosin and actin filaments using time-resolved FRET

F. L. Wong, T. A. Bunch, V. C. Lepak, B. A. Colson

This study uses TR-FRET to analyze cMyBP-C interactions with myosin and actin, revealing phosphorylation and mutation effects on binding, with implications for HCM therapy.

bioRxiv · Sep 7, 2022 · PreprintBiophysics

High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

T. A. Bunch, P. Guhathakurta, V. C. Lepak, A. R. Thompson, R.-S. Kannassatega, A. Wilson, D. D. Thomas, B. A. Colson

This study identifies small-molecule inhibitors of actin-cMyBP-C binding using a fluorescence lifetime assay and validates their mechanism with complementary techniques.

bioRxiv · Mar 24, 2021 · PreprintBiophysics

Age affects myosin relaxation states in skeletal muscle fibers of female but not male mice

L. A. Phung, S. M. Karvinen, B. A. Colson, D. D. Thomas, D. A. Lowe

This study finds that aging reduces myosin relaxation states (DRX and SRX) in female mice but not males, suggesting sex-specific effects on muscle aging.

bioRxiv · Jun 1, 2018Biochemistry