A. Wilson

A prelimbic molecular clock of protein synthesis for memory persistence

This study identifies a molecular clock in the prelimbic cortex that regulates protein synthesis for memory consolidation and reconsolidation through distinct translational pathways.

Corticosteroids prevent pathological angiogenesis yet compromise reparative vascular remodeling in the retina

This study shows corticosteroids inhibit early pathological angiogenesis but hinder reparative vascular remodeling in retinopathy.

Targeting Fatty Acid Desaturase I Inhibits Renal Cancer Growth Via ATF3-mediated ER Stress Response

This study shows that inhibiting FADS1 reduces renal cancer growth by inducing ER stress and ATF3-mediated responses, highlighting FADS1 as a therapeutic target.

Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19

This study shows that maternal extracellular vesicles from COVID-19 pregnancies alter trophoblast function, contributing to placental dysfunction.

Aging and intraocular pressure homeostasis in mice

This study examines how aging affects intraocular pressure regulation in mice, finding that outflow facility remains stable despite age-related tissue changes.

CREBBP lysine acetyltransferase domain mutations create zombie enzymes that alter chromatin loading dynamics and prevent EP300 redundancy

The paper shows that CREBBP mutations disrupt chromatin loading dynamics and EP300 redundancy, creating zombie enzymes that impair enhancer activation in GC B-cells and lymphoma.

Nitrite secretion by cyanobacteria is controlled by the small protein NirP1

This study identifies NirP1 as a regulator of nitrite secretion in cyanobacteria under carbon limitation, revealing its role in coordinating carbon and nitrogen metabolism.

A novel phenylpropanoid methyl esterase enables catabolism of aromatic compounds that inhibit biological nitrification

The paper identifies a novel phenylpropanoid methyl esterase that catabolizes aromatic biological nitrification inhibitors, enabling their use as carbon sources by bacteria.

Single-chain fluorescent integrators for mapping G-protein-coupled receptor agonists

The paper introduces SPOTIT and SPOTall sensors to detect GPCR agonist localization in the whole brain using fluorescent integrator sensors for multiple neuromodulators.

Sorgoleone degradation by sorghum-associated bacteria; an opportunity for enforcing plant growth promotion

The paper identifies bacterial strains capable of degrading sorgoleone, a plant exudate, and characterizes the genetic basis for this trait, offering potential for engineering beneficial plant-microbe interactions.

Misaligned plastic and evolutionary responses of lifespan to novel carbohydrate diets

This study shows that lifespan evolution and plasticity responses to carbohydrate diets in Drosophila serrata are misaligned, with plastic responses opposing evolutionary changes.

A human mesenchymal spheroid prototype to replace moderate severity animal procedures in leukaemia drug testing

This paper develops a human mesenchymal spheroid platform to replace animal testing in leukemia drug testing, showing faster results and better modeling of treatment resistance.

Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

DLK-dependent biphasic reactivation of herpes simplex virus latency established in the absence of antivirals

This paper introduces a new HSV-1 reporter virus, Stayput-GFP, to study latency and reactivation in neurons without antivirals, revealing DLK-dependent Phase I reactivation and histone demethylase-dependent Phase II reactivation.

Oligomerization processes limit photoactivation and recovery of the Orange Carotenoid Protein.

This study investigates the role of oligomerization in the photoactivation and recovery of the Orange Carotenoid Protein (OCP) using X-ray scattering and optical spectroscopy, revealing that oligomerization regulates its photocycle and slows thermal recovery.

Partial sex linkage and linkage disequilibrium on the guppy sex chromosome

The paper analyzes PoolSeq data from guppy populations to assess sex linkage and recombination suppression, finding evidence of linkage disequilibrium but no consistent male-specific variants.

Structure-function-dynamics relationships in the peculiar Planktothrix PCC7805 OCP1: impact of his-tagging and carotenoid type.

This paper characterizes the functional, structural, and dynamic properties of Planktothrix PCC7805 OCP, showing how carotenoid type and His-tagging affect its photoactivation and energy quenching.

A unifying perspective of the ultrafast photo-dynamics of Orange Carotenoid Protein from Synechocystis: peril of high-power excitation, existence of different S* states and influence of tagging

This paper investigates the ultrafast photo-dynamics of Orange Carotenoid Protein (OCP) from Synechocystis, revealing new excited states and the impact of excitation power and His-tagging on photo-activation.

The ColR/S two-component system is a conserved determinant of host association across Pseudomonas species

This study shows the ColR/S two-component system is conserved in Pseudomonas species and required for host association, but its regulon diverges between strains with different lifestyles.

Human airway lineages derived from pluripotent stem cells reveal the epithelial responses to SARS-CoV-2 infection

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

Asymmetric peptidoglycan editing generates the curvature of predatory bacteria, optimizing invasion and replication within a spherical prey niche

The paper identifies Bd1075 as a peptidoglycan-editing enzyme in Bdellovibrio bacteriovorus that generates asymmetric curvature, enhancing invasion and replication within spherical prey.

An ex vivo human bone marrow milieu identifies CDH2 as a driver of niche-mediated treatment resistance in leukaemia

This study identifies CDH2 as a driver of niche-mediated treatment resistance in leukemia and shows that ADH-1 can effectively target this resistance in preclinical models.

Loss of TDP-43 function and rimmed vacuoles persist after T cell depletion in a xenograft model of sporadic inclusion body myositis

Depletion of T cells in a xenograft model of sporadic inclusion body myositis suppresses inflammation but not TDP-43 pathology or muscle degeneration.

High-throughput screen using fluorescence lifetime detects compounds that modulate myosin-binding protein C interactions with actin

This study identifies small-molecule inhibitors of actin-cMyBP-C binding using a fluorescence lifetime assay and validates their mechanism with complementary techniques.

3D genomic capture of regulatory immuno-genetic profiles in COVID-19 patients for prognosis of severe COVID disease outcome

This study uses 3D genomic analysis of blood samples from COVID-19 patients to identify prognostic genomic markers that can stratify patients by disease severity.

Increased adaptive potential in novel environments can be predicted from genetic variance in development time expressed in native environments

The paper shows that genetic variation in development time in native environments predicts survival in novel environments, with faster development linked to better survival.

Sensory-based quantification of male colour patterns in Trinidadian guppies reveals nonparallel phenotypic evolution across an ecological transition in multivariate trait space

The paper quantifies male color patterns in Trinidadian guppies to assess phenotypic evolution across ecological transitions, finding nonparallel divergence in multivariate trait space.

The deubiquitinase (DUB) USP13 promotes Mcl-1 stabilisation in cervical cancer

This study identifies USP13 as an oncogene in cervical cancer that stabilizes Mcl-1, enhancing cell survival and sensitivity to ABT-263.

Telomere length is highly heritable and independent of growth rate manipulated by temperature in field crickets

The paper investigates telomere length heritability and its relationship with growth rate in field crickets, finding high heritability but no effect of growth rate on telomere length.

Actin-binding compounds, discovered by FRET-based high-throughput screening, differentially affect skeletal and cardiac muscle

This study evaluates actin-binding compounds identified through TR-FRET screening, showing differential effects on skeletal and cardiac muscle actin and myofibril function.