A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity Upon Viral Infection and Advanced Age
B. J. Joma, N. Siwapornchai, V. K. Vanguri, A. Shrestha, S. E. Roggensack, B. A. Davidson, A. Tai, A. P. Hakansson, S. N. Meydani, J. M. Leong, E. N. Bou Ghanem
This paper develops a murine model showing that viral infection and aging enhance Streptococcus pneumoniae pathogenicity through altered bacterial behavior, neutrophil dysfunction, and increased lung bacterial growth.
bioRxiv · Jul 29, 2020Microbiology