Author

K. Odunsi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cancer Biology· 3

Signature Assays, Organisms & Methods

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Organism:human· 7 Approach:experimental assay· 6 Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Research Focus:differential expression· 5 Research Focus:cell-cell communication· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 2

Frequent Co-Authors

S. Battaglia· 3 shared A. R. McGray· 2 shared B. D. Litchy· 2 shared B. H. Segal· 2 shared H. Yu· 2 shared J. Wang· 2 shared R. MUTHUSWAMY· 2 shared A. Amobi-McCloud· 1 shared

Activity by Year

2019-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

S. Battaglia

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Cancer relevance of circulating antibodies against LINE-1 antigens in humans

A. Vylegzhanina, I. Bespalov, K. Novototskaya-Vlasova, B. Hall, A. Gleiberman, H. Yu, O. Leontieva, K. Leonova, O. Kurnasov, A. Osterman, G. Dy, A. Komissarov, E. Vasilieva, J. Gehlhausen, A. Iwasaki, , A. V. Gudkov

The paper detects higher levels of anti-LINE-1 protein antibodies in cancer patients compared to healthy individuals, suggesting potential diagnostic value for early cancer detection.

bioRxiv · Feb 3, 2023Cancer Biology

Indoleamine 2,3-dioxygenase upregulates PD-1 expression on ovarian tumor infiltrating CD8+ T cells via kynurenine activation of the aryl hydrocarbon receptor

A. Amobi-McCloud, R. MUTHUSWAMY, S. Battaglia, H. Yu, T. Liu, J. Wang, V. Putluri, P. K. Singh, F. Qian, R.-Y. Huang, N. Putluri, T. Takemasa, A. Lugade, S. Liu, K. Odunsi

This study shows that IDO1 promotes PD-1 expression on CD8+ T cells in ovarian tumors through kynurenine-mediated AHR activation, suggesting therapeutic targeting of these pathways.

bioRxiv · Feb 18, 2021 · PreprintImmunology

CXCR6 by increasing retention of memory CD8 T cells in the ovarian tumor microenvironment promotes immunosurveillance and control of ovarian cancer

R. Muthuswamy, A. R. McGray, S. Battaglia, W. He, A. Miliotto, C. A. Eppolito, B. D. Litchy, P. Shrikant, K. Odunsi, K. Odunsi

This study identifies CXCR6 as a marker for resident memory CD8 T cells in ovarian cancer, showing its role in enhancing tumor immunosurveillance through increased retention of these cells in the tumor microenvironment.

bioRxiv · Dec 2, 2020Immunology

Extensive Intratumor Proteogenomic Heterogeneity Revealed by Multiregion Sampling in High-Grade Serous Ovarian Tumor Specimens

A. L. Hunt, N. W. Bateman, W. Barakat, S. Makohon-Moore, B. L. Hood, K. A. Conrads, M. Zhou, V. Calvert, M. Pierobon, J. Loffredo, T. J. Litzi, J. Oliver, D. Mitchell, G. Gist, C. Rojas, , T. P. Conrads

The paper analyzes proteogenomic heterogeneity in ovarian tumors using multiregion sampling and reveals distinct expression patterns between tumor epithelium and stroma.

bioRxiv · Oct 6, 2020 · PreprintCancer Biology

A circulating T-cell differentiation marker to predict response to immune checkpoint inhibitors

T. Yamauchi, T. Hoki, T. Oba, V. Jain, H. Chen, K. Attwood, S. Battaglia, S. George, G. Chatta, I. Puzanov, C. Morrison, K. Odunsi, B. H. Segal, G. K. Dy, M. S. Ernstoff, F. Ito

The paper identifies CX3CR1 expression on circulating CD8+ T cells as a biomarker predicting response to immune checkpoint inhibitor therapy in NSCLC patients.

bioRxiv · Jun 13, 2020Immunology

RNA editing enzyme APOBEC3A promotes pro-inflammatory (M1) macrophage polarization

E. Y. Alqassim, S. Sharma, A. N. H. Khan, T. Emmons, E. Cortes-Gomez, K. Singel, J. Mark, B. A. Davidson, A. R. McGray, Q. Liu, B. D. Litchy, K. Moysich, J. Wang, K. Odunsi, B. H. Segal, B. E. Baysal

This study shows APOBEC3A promotes M1 macrophage polarization through RNA editing, affecting gene expression and cytokine secretion.

bioRxiv · Mar 20, 2020Immunology

Co-regulation and functional cooperativity of FOXM1 and RHNO1 bidirectional genes in ovarian cancer

C. J. Barger, C. Branick, L. Chee, M. Albahrani, D. Klinkebiel, R. Drapkin, K. Odunsi, L. Zou, A. Karpf

This study identifies functional cooperativity between FOXM1 and RHNO1 bidirectional genes in ovarian cancer and suggests combinatorial targeting as a therapeutic strategy.

bioRxiv · Jun 4, 2019Cancer Biology