MicrobiologybioRxiv
A Murine Model for Enhancement of Streptococcus pneumoniae Pathogenicity Upon Viral Infection and Advanced Age
B. J. Joma, N. Siwapornchai, V. K. Vanguri…·E. N. Bou Ghanem
This paper develops a murine model showing that viral infection and aging enhance Streptococcus pneumoniae pathogenicity through altered bacterial behavior, neutrophil dysfunction, and increased lung bacterial growth.
DOI 10.1128/iai.00471-20