Cancer BiologybioRxiv
Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling
K. Rubio, A. Romero, P. Sarvari…·G. Barreto
This study identifies a non-canonical ITGB2 signaling pathway that activates EGFR and RAS/MAPK/ERK in SCLC, leading to aggressive tumor behavior and resistance to EGFR inhibitors.
DOI 10.7150/thno.79493