Extracellular vesicles induce aggressive lung cancervia non-canonical integrin-EGFR-KRAS signaling
K. Rubio, A. Romero, P. Sarvari, S. Guenther, A. Mehta, B. Bassaly, P. Braubach, G. Dobreva, M. Wygrecka, S. Gattenloehner, T. Braun, A. Tresch, J. Graumann, G. Barreto
This study identifies a non-canonical ITGB2 signaling pathway that activates EGFR and RAS/MAPK/ERK in SCLC, leading to aggressive tumor behavior and resistance to EGFR inhibitors.
bioRxiv · Aug 16, 2022Cancer Biology