Author

B. Bottcher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Microbiology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

T. Rasmussen· 2 shared A. A. Inoue· 1 shared A. Allikalt· 1 shared A. Basbaum· 1 shared A. Ullrich· 1 shared B. K. Shoichet· 1 shared C. Kraft· 1 shared D. Weikert· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersBiophysics

T. Rasmussen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Lymphostatin: Structure of a large multi-functional virulence factor

M. Griessmann, T. Rasmussen, V. J. Flegler, C. Kraft, R. Schneider, L. Spantzel, M. Stevens, M. Borsch, B. Bottcher

This paper determines the structure of lymphostatin, a multifunctional virulence factor in E. coli, revealing its domains and mechanism of action.

bioRxiv · May 21, 2024Biophysics

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology

Immediate targeting of host ribosomes by jumbo phage encoded proteins

M. Gerovac, K. Chihara, L. Wicke, B. Bottcher, R. Lavigne, J. Vogel

This study identifies phage-encoded proteins that target host ribosomes to modulate translation in Pseudomonas aeruginosa.

bioRxiv · Feb 26, 2023 · PreprintMicrobiology