R. Schneider

A comprehensive study of SARS-CoV-2 main protease (Mpro) inhibitor-resistant mutants selected in a VSV-based system

This study identifies and characterizes SARS-CoV-2 Mpro mutations conferring resistance to nirmatrelvir using a VSV-based system and biochemical assays.

IL-1R signaling drives enteric glia-macrophage interactions in colorectal cancer

This study identifies IL-1R signaling as a driver of enteric glia-macrophage interactions in colorectal cancer, promoting tumor progression through IL-6 secretion.

A Unique Polyfunctional IL-33-responsive ST2⁺ NK cell State Potentiates Antitumor Immunity and Response to Immunotherapy

The paper identifies a unique ST2+ NK cell state that enhances antitumor immunity and response to immunotherapy through IL-33 and IL-12 signaling.

3D-Mass Spectrometry Imaging of Micro-scale 3D Cell Culture Models in Cancer Research

The paper presents a 3D-MSI platform for analyzing lipid distribution in 3D cell cultures, revealing metabolic interactions in cancer models.

Nucleation complex behaviour is critical for cortical microtubule array homogeneity and patterning

This study shows that limited nucleation complex recruitment to microtubules balances positive feedback, enabling cortical microtubule array patterning in plant cells.

Arabidopsis PFA-DSP-type phosphohydrolases target specific inositol pyrophosphate messengers

This study identifies Arabidopsis PFA-DSP proteins as specific inositol pyrophosphate phosphohydrolases, revealing their role in regulating these signaling molecules.

Large-scale conformational changes of FhaC provide insights into the two-partner secretion mechanism

The paper investigates conformational changes in FhaC, a TpsB transporter, revealing how it facilitates protein secretion without external energy sources through intrinsic dynamics.

Systematic identification of yeast mutants with increased rates of cell death reveals rapid stochastic necrosis associated with cell division

The paper identifies yeast mutants with increased cell death during division, revealing rapid stochastic necrosis linked to genetic perturbations and cell-wall integrity.

Oral administration of a single anti-CfaE nanobody provides broadly cross-protective immunity against major pathogenic Enterotoxigenic Escherichia coli strains

This study shows that oral administration of a single nanobody provides broad protection against multiple ETEC strains by targeting conserved epitopes.

ITPK1 is an InsP6/ADP phosphotransferase that controls systemic phosphate homeostasis in Arabidopsis

This study shows ITPK1 generates PP-InsPs from InsP6 and regulates phosphate homeostasis in Arabidopsis by controlling InsP7 and InsP8 synthesis.

IgA MAb blocks SARS-CoV-2 Spike-ACE2 interaction providing mucosal immunity

This study identifies an IgA monoclonal antibody that blocks SARS-CoV-2 Spike-ACE2 interaction and provides mucosal immunity.

First-in-class matrix anti-assembly peptide prevents staphylococcal biofilm in vitro and in vivo

This study develops a plant-inspired peptide that prevents staphylococcal biofilm formation in vitro and in vivo by disrupting matrix assembly.

Long-term single-cell imaging and simulations of microtubules reveal driving forces for wall pattering during proto-xylem development

The paper uses live-cell imaging and simulations to study microtubule re-organization during proto-xylem development, revealing the role of local nucleation and KATANIN recruitment in wall pattern formation.

Melanoma-secreted Amyloid Beta Supresses Neuroinflammation and Promotes Brain Metastasis

This study identifies amyloid beta as a factor secreted by melanoma cells that suppresses neuroinflammation and promotes brain metastasis.

Pathogenic Budding Yeasts Isolated outside of Clinical Settings

The paper isolates pathogenic budding yeasts from non-clinical environments, finding associations with fruits, soil, and plants, challenging the assumption that these yeasts are only contaminants.