Author

A. Basbaum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Pharmacology & Toxicology· 2 Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 4 Organism:mouse· 4 Approach:experimental assay· 3 Approach:deep learning· 2 Assay:proteomics· 2 Approach:statistical model· 1 Assay:structural biology· 1

Frequent Co-Authors

B. K. Shoichet· 4 shared B. L. Roth· 3 shared H. R. O'Donnell· 2 shared J. Braz· 2 shared J. M. Braz· 2 shared K. Bhardwaj· 2 shared P. Lak· 2 shared S. Rodriguez-Rosado· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPharmacology & Toxicology

B. K. Shoichet

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Structure-Based Discovery of a NPFF1R Antagonist with Analgesic Activity

B. J. Bender, J. E. Pickett, J. Braz, H. J. Kang, S. Gahbauer, K. Bhardwaj, S. Rodriguez-Rosado, Y. Liu, M. Jain, A. Basbaum, B. L. Roth, B. K. Shoichet

This paper identifies a selective NPFF1R antagonist with analgesic properties, showing enhanced pain relief when combined with morphine and reduced side effects.

bioRxiv · Oct 25, 2023 · PreprintPharmacology & Toxicology

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

A. Ullrich, J. Schneider, J. M. Braz, E. Neu, N. Staffen, M. Stanek, J. Blahova, T. Hove, T. Albert, A. Allikalt, S. Lober, K. Bhardwaj, S. Rodriguez-Rosado, E. A. Fink, T. Rasmussen, , P. Gmeiner

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

bioRxiv · Sep 11, 2023 · PreprintPharmacology & Toxicology

Structure-based Discovery of Conformationally Selective Inhibitors of the Serotonin Transporter

I. Singh, A. Seth, C. B. Billesbolle, J. Braz, R. M. Rodriguiz, K. Roy, B. Bekele, V. Craik, X.-P. Huang, D. Boytsov, P. Lak, H. R. O'Donnell, W. R. Sandtner, B. L. Roth, A. Basbaum, , G. Rudnick

The paper identifies two novel inhibitors of the serotonin transporter that selectively target the inward-open conformation, showing improved potency and reduced off-target effects compared to existing drugs.

bioRxiv · Jun 13, 2022Biochemistry

Structure-based design of a chemical probe set for the 5-HT5A serotonin receptor

A. L. Kaplan, R. T. Strachan, J. M. Braz, V. Craik, S. Slocum, T. Mangano, V. Amabo, H. R. O'Donnell, P. Lak, A. Basbaum, B. L. Roth, B. K. Shoichet

The paper develops a more selective chemical probe set for the 5-HT5A receptor, showing improved selectivity and reduced assay liabilities compared to the existing SB-699551 antagonist.

bioRxiv · Dec 6, 2021 · PreprintBiophysics