J. Schneider

Discovery of a functionally selective serotonin 5-HT1A receptor agonist for the treatment of pain

The paper identifies ST171, a selective 5-HT1A receptor agonist effective in pain models without sedation, and elucidates its mechanism through structural and computational analysis.

Serial Lift-Out - Sampling the Molecular Anatomy of Whole Organisms

This paper introduces Serial Lift-Out, a technique that improves sample preparation for cryo-ET, enabling the study of multicellular molecular anatomy in C. elegans.

Crosslinking by ZapD drives the assembly of short FtsZ filaments into toroidal structures in solution

This study shows ZapD crosslinks FtsZ filaments into toroidal structures, revealing how crosslinking density and geometry enable Z ring formation in bacteria.

Repurposing of the antibiotic nitroxoline for the treatment of mpox

This study shows nitroxoline, an antibiotic, inhibits mpox virus replication and remains effective against tecovirimat-resistant strains, suggesting it as a repurposing candidate for mpox treatment.

A conserved and tunable mechanism for the temperature-controlled condensation of the translation factor Ded1p

The paper investigates how Ded1p translation factors assemble into condensates in response to heat across fungi, identifying structural and amino acid determinants of temperature sensitivity.

Reliability and accuracy of single-molecule FRET studies for characterization of structural dynamics and distances in proteins

This study evaluates the reliability and accuracy of single-molecule FRET for measuring protein structural dynamics and distances, finding high precision and accuracy with specific uncertainty limits.

The faecal metabolome and its determinants in inflammatory bowel disease

This study identifies metabolic alterations in IBD patients by analyzing faecal metabolites, metagenomics, host genetics, and clinical data, finding over 300 differentially abundant molecules and associations with microbiota and diet.

SARS-CoV-2-specific T cells associate with reduced lung function and inflammation in pulmonary post-acute sequalae of SARS-CoV-2

This study finds that elevated SARS-CoV-2-specific T cells in individuals with pulmonary PASC correlate with increased inflammation and reduced lung function.

Gut Bacterial Dysbiosis and Instability is Associated with the Onset of Complications and Mortality in COVID-19

The paper analyzes gut and oral microbiota in COVID-19 patients to show associations between microbial dysbiosis, complications, and mortality.

Molecular-scale visualization of sarcomere contraction within native cardiomyocytes

This study uses cryo-electron tomography to visualize sarcomere contraction in neonatal rat cardiomyocytes, revealing thin filament sliding and structural changes during muscle contraction.

Molecular phylogenetics and micromorphology of Australasian Stipeae (Poaceae), and the interrelation of whole-genome duplication and evolutionary radiations in this grass tribe

The paper investigates the molecular phylogenetics and micromorphology of Austrostipa, revealing subgenus classifications, hybrid origins, and evolutionary relationships within the Stipeae tribe.

2'3'-cGAMP triggers a STING and NF-κB dependent broad antiviral response in Drosophila

This study shows that 2'3'-cGAMP activates dSTING and NF-κB to trigger a broad antiviral response in Drosophila, independent of autophagy and RNAi pathways.

The Evolution of Social Organization: Climate Influences Variation in Drosophilid Social Networks

This study examines how climate influences social interaction networks in Drosophilid species, finding that past climate predicts current network properties while phylogeny explains some behavioral traits.

Phylogeny, morphology and the role of hybridization as driving force of evolution in grass tribes Aveneae and Poeae (Poaceae)

This study investigates the evolutionary diversification and morphological evolution of grass tribes Aveneae and Poeae by analyzing molecular phylogenetics and morphological traits, revealing hybridization as a key driver of speciation.

Energy-dependent transport at dural lymphatic vessels is necessary for Aβ brain clearance in Alzheimer's disease

The paper shows that energy-dependent transport in dural lymphatic vessels is critical for clearing Aβ in Alzheimer's disease, and blocking this pathway accelerates Aβ pathology.

BIN1 protein isoforms are differentially expressed in astrocytes, neurons, and microglia: neuronal and astrocyte BIN1 implicated in Tau pathology

The paper identifies BIN1 protein isoforms expressed in astrocytes, neurons, and microglia, finding that neuronal and astrocytic BIN1 containing exon 7 is associated with tau pathology in Alzheimer's disease.

Can Drosophila melanogaster tell who’s who?

This study shows that individual Drosophila melanogaster can be visually distinguished using machine learning, suggesting their visual system can process and encode sufficient information for recognition.

Magnetic resonance imaging of the regenerating neonatal mouse heart

This study uses MRI to track neonatal mouse heart regeneration after coronary artery ligation, showing regenerative responses in P1 animals versus fibrotic responses in P7 animals.