M. Lethier

Structural analysis shows that the BIR2 domain of E3 ligase XIAP binds across the RIP2 kinase dimer interface

The paper determines the structure of the RIP2K-XIAP BIR2 complex, revealing its dimeric conformation and molecular mechanisms of interaction.

Mechanistic insights into RNA binding and RNA-regulated RIG-I ubiquitination by TRIM25

This study identifies RNA binding sites on TRIM25 and shows that RNA binding enhances its E3 ligase activity and affects RIG-I ubiquitination.