Single Cell and Spatial Transcriptomics Defines the Cellular Architecture of the Antimicrobial Response Network in Human Leprosy Granulomas
F. Ma, T. K. Hughes, R. M. B. Teles, P. R. Andrade, B. J. d. A. Silva, O. Plazyo, L. C. Tsoi, T. Do, M. H. Wadsworth, A. Oulee, M. T. Ochoa, E. N. Sarno, M. L. Iruela-Arispe, B. Bryson, A. K. Shalek, , R. L. Modlin
The paper uses single cell and spatial transcriptomics to map the cellular architecture of antimicrobial responses in leprosy granulomas, identifying gene expression differences and spatial organization in reversal reactions.
bioRxiv · Dec 1, 2020 · PreprintImmunology