Author

B. Casu

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:bacteria (other)· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:imaging· 2 Organism:C. elegans· 1 Research Focus:cell signaling & trafficking· 1 Approach:microscopy & imaging analysis· 1

Frequent Co-Authors

M. Pilhofer· 3 shared C. Baron· 2 shared J. Sygusch· 2 shared J. W. Sallmen· 2 shared S. Schlimpert· 2 shared T. Arya· 2 shared A. Marinier· 1 shared B. Bessette· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersMicrobiology

M. Pilhofer

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Function and firing of the Streptomyces coelicolor contractile injection system requires the membrane protein CisA

B. Casu, J. W. Sallmen, P. E. Haas, G. Chandra, P. Afanasyev, J. Xu, M. Pilhofer, S. Schlimpert

This study identifies CisA as a membrane protein essential for the function of the Streptomyces coelicolor contractile injection system, showing it mediates recruitment to the membrane and firing.

eLife · Jul 8, 2025Peer-reviewedMicrobiology

Structure-based design of small molecule inhibitors of the cagT4SS ATPase Cagα of Helicobacter pylori

C. Morin, V. T. Verma, T. Arya, B. Casu, E. Jolicoeur, R. Ruel, A. Marinier, J. Sygusch, C. Baron

The paper designs small molecule inhibitors of the cagT4SS ATPase Cagα in Helicobacter pylori using structure-based approaches and identifies five potent inhibitors that inhibit ATPase activity and T4SS pili assembly.

bioRxiv · Nov 6, 2023Biochemistry

Co-chaperone-mediated post-translational control of efflux pump induction underlies adaptive β-lactam resistance in Caulobacter crescentus.

J. Costafrolaz, G. Panis, B. Casu, S. Ardissone, L. Degeorges, M. Pilhofer, P. H. Viollier

bioRxiv · Feb 20, 2023 · PreprintMicrobiology

Cytoplasmic contractile injection systems mediate cell death in Streptomyces

B. Casu, J. W. Sallmen, S. Schlimpert, M. Pilhofer

This study characterizes a contractile injection system in Streptomyces coelicolor that mediates cell death under stress and affects development.

bioRxiv · Aug 9, 2022Microbiology

Fragment-based screening identifies inhibitors of the ATPase activity and of hexamer formation of Cagα from the Helicobacter pylori type IV secretion system

T. Arya, F. Oudouhou, B. Casu, B. Bessette, J. Sygusch, C. Baron

The paper identifies inhibitors of Cagα's ATPase activity and hexamer formation using fragment-based screening, revealing a novel mechanism for antivirulence drug development.

bioRxiv · May 20, 2018Microbiology