Author

P. Afanasyev

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:protein folding & dynamics· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Assay:electronic health records· 1 Assay:protein structure· 1

Frequent Co-Authors

D. Boehringer· 2 shared T. Wiegand· 2 shared A. Arm· 1 shared A. Terakita· 1 shared A. Toste Rego· 1 shared C. Eichmann· 1 shared C.-J. Tsai· 1 shared D. M. Pfizenmaier· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersBiochemistry

D. Boehringer

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Author profile →

4 papers

Recent·Most cited

Active state structures of a bistable visual opsin bound to G proteins

O. Tejero, F. K. Pamula, M. Koyanagi, T. Nagata, P. Afanasyev, I. Das, X. Deupi, M. Sheves, A. Terakita, G. F. X. Schertler, M. J. Rodrigues, C.-J. Tsai

This study presents active state structures of a bistable opsin, JSR1, bound to G proteins, revealing differences in activation mechanisms between monostable and bistable opsins.

bioRxiv · Apr 9, 2024Biochemistry

A solid beta-sheet structure is formed at the surface of FUS liquid droplets during aging

L. Emmanouilidis, E. Bartalucci, Y. Kan, M. Ijavi, M. E. Perez, P. Afanasyev, D. Boehringer, J. Zehnder, S. H. Parekh, M. Bonn, T. C. T. Michaels, T. Wiegand, F. H.- T. Allain

This study investigates FUS liquid droplet maturation, revealing a solid beta-sheet surface layer that forms during aging, with RNA inhibiting this process.

bioRxiv · Jun 2, 2023Biochemistry

A conserved mechanism regulates reversible amyloids via pH-sensing regions

G. Cereghetti, V. M. Kissling, L. M. Koch, A. Arm, P. Afanasyev, M. Linsenmeier, C. Eichmann, J. Zhou, Y. Cao, D. M. Pfizenmaier, S. Kroschwald, T. Wiegand, R. Cadalbert, D. Boehringer, R. Mezzenga, , M. Peter

This study identifies a conserved mechanism by which pH-sensing regions regulate reversible amyloid formation in pyruvate kinase across yeast and human cells.

bioRxiv · Mar 21, 2022 · PreprintCell Biology

New insights into the human 26S proteasome function and regulation

M. Kisonaite, P. Afanasyev, J. Tafilaku, A. Toste Rego, P. C. A. da Fonseca

The paper investigates the human 26S proteasome function and regulation through structural analysis, revealing conformational states and allosteric communication mechanisms.

bioRxiv · Oct 3, 2021 · PreprintBiochemistry