Author

M. Pilhofer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 10 Cell Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:cell type annotation· 5 Organism:bacteria (other)· 4 Research Focus:host-pathogen & immune response· 4 Assay:imaging· 4 Assay:cryo-EM· 3 Approach:microscopy & imaging analysis· 3 Assay:proteomics· 3

Frequent Co-Authors

G. L. Weiss· 3 shared J. Xu· 3 shared A.-K. Kieninger· 2 shared B. Casu· 2 shared D. Böck· 2 shared I. Maldener· 2 shared A. Briegel· 1 shared A. Henggeler· 1 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 8 mutual co-author links

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3 shared papersMicrobiology

G. L. Weiss

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Archaeal type six secretion system mediates contact-dependent antagonism

T. Zachs, J. J. L. Malit, J. Xu, A. Schürch, S. Sivabalasarma, P. Nussbaum, S.-V. Albers, M. Pilhofer

The paper identifies a contact-dependent antagonism mechanism in archaea mediated by a CIS similar to bacterial T6SSs, revealing its role in shaping microbial communities.

Science Advances · Nov 15, 2024Peer-reviewedMicrobiology

FilamentID reveals the composition and function of metabolic enzyme polymers during gametogenesis

J. Hugener, J. Xu, R. Wettstein, L. Ioannidi, D. Velikov, F. Wollweber, A. Henggeler, J. Matos, M. Pilhofer

The paper introduces FilamentID, a workflow to identify filament composition in cells, finding Ald4ALDH2 and Acs1ACSS2 form filaments in mitochondria and nucleus during meiosis, aiding cell recovery from stress.

bioRxiv · Mar 26, 2024Cell Biology

Mechanism of bacterial predation via ixotrophy

Y.-W. Lien, D. Amendola, K. S. Lee, N. Bartlau, J. Xu, G. Furusawa, M. F. Polz, R. Stocker, G. L. Weiss, M. PIlhofer

This study identifies the molecular mechanisms of ixotrophy in bacteria, revealing the role of multiple secretion systems and regulatory elements in predatory behavior.

bioRxiv · Jan 29, 2024Microbiology

Co-chaperone-mediated post-translational control of efflux pump induction underlies adaptive β-lactam resistance in Caulobacter crescentus.

J. Costafrolaz, G. Panis, B. Casu, S. Ardissone, L. Degeorges, M. Pilhofer, P. H. Viollier

bioRxiv · Feb 20, 2023 · PreprintMicrobiology

The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila

D. Hüsler, P. Stauffer, B. Keller, D. Böck, T. Steiner, A. Ostrzinski, B. Striednig, L. Swart, F. Letourneur, S. Maass, D. Becher, W. Eisenreich, M. Pilhofer, H. Hilbi

This paper shows that Sey1 facilitates lipid droplet and FadL-dependent fatty acid metabolism in Legionella pneumophila by promoting interactions between the Legionella-containing vacuole and lipid droplets.

bioRxiv · Dec 5, 2022Microbiology

Cytoplasmic contractile injection systems mediate cell death in Streptomyces

B. Casu, J. W. Sallmen, S. Schlimpert, M. Pilhofer

This study characterizes a contractile injection system in Streptomyces coelicolor that mediates cell death under stress and affects development.

bioRxiv · Aug 9, 2022Microbiology

Gram-positive bacteria evade phage predation through endolysin-mediated L-form conversion

J. C. Wohlfarth, M. Feldmueller, A. Schneller, S. Kilcher, M. Burkolter, M. Pilhofer, M. Schuppler, M. J. Loessner

This paper shows Gram-positive bacteria like Listeria monocytogenes and Enterococcus faecalis can evade phage predation by temporarily converting to L-forms, which are wall-deficient but viable cells.

bioRxiv · May 24, 2022 · PreprintMicrobiology

SepN is essential for assembly and gating of septal junctions in Nostoc sp. PCC 7120

A.-K. Kieninger, P. Tokarz, G. L. Weiss, M. Pilhofer, I. Maldener

This study identifies SepN as a critical component of septal junctions in Nostoc sp. PCC 7120, showing its role in assembly and gating of intercellular communication.

bioRxiv · Jan 26, 2022 · PreprintMicrobiology

Bacterial Phage Tail-like Structure Kills Eukaryotic Cells by Injecting a Nuclease Effector

I. Rocchi, C. Ericson, K. E. Malter, S. Zargar, F. Eisenstein, M. Pilhofer, S. Beyhan, N. J. Shikuma

This study identifies Pne1, a nuclease effector delivered by bacterial CIS MACs, which kills eukaryotic cells by injecting it into target cells.

bioRxiv · Feb 11, 2019Microbiology

Structure and function of a bacterial gap junction analog

G. L. Weiss, A.-K. Kieninger, I. Maldener, K. Forchhammer, M. Pilhofer

The paper resolves the structure of bacterial septal junctions and shows they gate intercellular communication through conformational changes mediated by proteins FraC/D.

bioRxiv · Nov 5, 2018Cell Biology

In situ and high-resolution Cryo-EM structure of the Type VI secretion membrane complex

C. Rapisarda, Y. Cherrak, R. Kooger, V. Schmidt, R. Pellarin, L. Logger, E. Cascales, M. Pilhofer, E. Durand, R. Fronzes

The paper presents in situ cryo-EM structures of the T6SS membrane complex, revealing its 5-fold symmetry and new structural features.

bioRxiv · Oct 13, 2018Microbiology

The in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin

S. Cai, D. Böck, M. Pilhofer, L. Gan

This study uses cryo-ET to determine the in situ structures of mono-, di-, and tri-nucleosomes in human heterochromatin, revealing irregular paths and conformational variability.

bioRxiv · May 30, 2018Cell Biology

Uncharacterized bacterial structures revealed by electron cryotomography

M. J. Dobro, C. M. Oikonomou, A. Piper, J. Cohen, K. Guo, T. Jensen, J. Tadayon, J. Donermeyer, Y. Park, B. A. Solis, A. Kjaer, A. I. Jewett, A. W. McDowall, S. Chen, Y.-W. Chang, , G. J. Jensen

The paper presents uncharacterized bacterial structures observed via electron cryotomography to encourage their identification and study.

bioRxiv · Feb 13, 2017Microbiology