Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse
F. Seehusen, J. J. Clark, P. Sharma, E. Bentley, A. Kirby, K. Subramaniam, S. Wunderlin Giuliani, G. Hughes, E. I. Patterson, B. D. Michael, A. Owen, J. A. Hiscox, J. P. Stewart, A. Kipar
This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.
bioRxiv · Apr 16, 2021Pathology