J. A. Hiscox

This study shows that a recombinant SARS-CoV-2 virus lacking ORF10 start and internal methionine codons is attenuated in hamsters, with reduced lower respiratory tract viral titre and increased reversion to wild-type.

The paper identifies NSP12's interaction with the TRiC complex and shows the P323L substitution enhances viral adaptation by reducing sensitivity to PP2A perturbations.

The paper identifies minor variant genomes of SARS-CoV-2 early in the pandemic that contain substitutions later found in variants of concern.

This study compares the severity of SARS-CoV-2 Omicron-B.1.1.529, Pango B, and Delta variants in a mouse model, finding Omicron causes less severe disease with lower viral load and inflammation.

The paper tracks the rapid emergence of the P323L mutation in SARS-CoV-2 polymerase in human and non-human primate models, showing it confers a larger plaque phenotype compared to P323.

This study uses direct RNA sequencing to analyze RSV mRNA transcripts in infected cells, revealing gene abundance patterns and polyadenylate tail lengths.

This study evaluates the antiviral activity of molnupiravir's active metabolite NHC against SARS-CoV-2 variants, finds no resistance after 20 passages, and suggests earlier administration for better efficacy.

This paper demonstrates that a multimerised SARS-CoV-2 RBD vaccine using a stable scaffold provides enhanced antibody responses and complete protection in mice.

The paper identifies spike mutations that adapt SARS-CoV-2 to mustelid hosts and assesses their impact on human infectivity and antigenicity.

This study investigates SARS-CoV-2 variant neuroinvasion in K18-hACE2 mice, finding CNS spread in all variants except Omicron, with microglial activation and immune cell apoptosis observed.

The paper analyzes SARS-CoV-2 sequence variation in patient samples and compares the in vitro growth of B.1.1.7 and B.1.351 variants to other isolates, finding no significant difference in growth for B.1.1.7.

This study shows that prior SARS-CoV-2 infection in Syrian Golden Hamsters protects against re-exposure to variants B.1.1.7 and B.1.351, suggesting immunity may limit disease from emerging variants.

The paper identifies and quantifies SARS-CoV-2 leader-TRS-junctions in samples, showing phasic sgmRNA transcription in animal models and dysregulation in humans.

This study investigates the dose-dependent response of ferrets to SARS-CoV-2 infection, showing protection against re-challenge and mild clinical disease.

This study shows that sequential infection with influenza A virus followed by SARS-CoV-2 in mice leads to more severe disease and encephalitis compared to single infections.

This study shows that SARS-CoV-2's S1 protein binds to NRP1 via the CendR motif, enhancing infection and identifying NRP1 as a therapeutic target.

The paper investigates EV71 infection in human cells, identifies TREM-1 activation as a key driver of severe disease, and shows its role in inflammation and viral load.

This study assesses metagenomic sequencing using MinION and Illumina to recover whole genomes of chikungunya and dengue viruses from clinical samples, showing high feasibility for phylogenetic analysis.