Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
U. Schmitz, S. A. Gilmore, D. Tam, T. L. Cheung, C. Snyder, J. Farand, R. Dick, M. Matles, J. Y. Feng, R. Ramirez, L. Li, H. Yu, Y. Xu, D. Barnes, G. Czerwieniec, , B. Feierbach
This study identifies a KDM5 inhibitor with anti-HBV activity in vitro but not in vivo, highlighting challenges in translating epigenetic therapies to viral infections.
bioRxiv · Jun 27, 2022 · PreprintPharmacology & Toxicology