Pharmacology & ToxicologybioRxiv
Discovery of GS-5245 (Obeldesivir), an Oral Prodrug of Nucleoside GS-441524 that Exhibits Antiviral Efficacy in SARS-CoV-2 Infected African Green Monkeys
DOI 10.1021/acs.jmedchem.3c00750
Author
J. Y. Feng
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
Click to filter author papersSignature Assays, Organisms & Methods
Click to filter · or open tagActivity by Year
2020-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 45 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship7 papers
Recent·Most cited
- BiochemistrybioRxiv
Interfering with nucleotide excision by the coronavirus 3'-to-5' exoribonuclease
R. Chinthapatla, M. S. Sotoudegan, T. Anderson…·J. J. Arnold
This study investigates how SARS-CoV-2's ExoN enzyme processes RNA and identifies modifications that block its activity, offering potential for new antiviral strategies.
DOI 10.1093/nar/gkac1177 - Pharmacology & ToxicologybioRxivPreprint
Characterization of a KDM5 Small Molecule Inhibitor with Antiviral Activity against Hepatitis B Virus
U. Schmitz, S. A. Gilmore, D. Tam…·B. Feierbach
This study identifies a KDM5 inhibitor with anti-HBV activity in vitro but not in vivo, highlighting challenges in translating epigenetic therapies to viral infections.
- BiophysicsbioRxiv
Structural basis for substrate selection by the SARS-CoV-2 replicase
B. F. Malone, J. K. Perry, P. D. B. Olinares…·S. A. Darst
This study uses cryo-EM to reveal how the SARS-CoV-2 RTC discriminates between natural NTPs and the antiviral remdesivir triphosphate, providing insights for antiviral design.
DOI 10.1038/s41586-022-05664-3 - BiochemistrybioRxiv
Efficient incorporation and template-dependent polymerase inhibition are major determinants for the broad-spectrum antiviral activity of remdesivir
M. Götte, C. J. Gordon, H. W. Lee…·D. P. Porter
This study investigates how remdesivir's antiviral activity varies across RNA viruses by analyzing its incorporation and inhibition mechanisms in different polymerases.
DOI 10.1016/j.jbc.2021.101529 - MicrobiologybioRxivPreprint
Therapeutic efficacy of an oral nucleoside analog of remdesivir against SARS-CoV-2 pathogenesis in mice.
A. Schafer, D. R. Martinez, J. J. Won…·T. P. Sheahan
This paper evaluates the therapeutic efficacy of GS-621763, an oral prodrug of remdesivir, against SARS-CoV-2 in mice, showing reduced viral load and improved lung function.
DOI 10.1101/2021.09.13.460111 - MicrobiologybioRxiv
Remdesivir potently inhibits SARS-CoV-2 in human lung cells and chimeric SARS-CoV expressing the SARS-CoV-2 RNA polymerase in mice.
A. J. Pruijssers, A. S. George, A. Schäfer…·T. P. Sheahan
This study shows remdesivir effectively inhibits SARS-CoV-2 in human cells and mice, reducing viral load and improving lung function.