Author

B. Flath

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Organism:chicken / avian· 1

Frequent Co-Authors

L. Chelico· 3 shared A. Gaba· 2 shared G. A. Cisneros· 2 shared M. A. Hix· 2 shared M. Emerman· 2 shared B. Boysan· 1 shared D. R. Williams· 1 shared F. Morcos· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 34 mutual co-author links

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3 shared papersBiochemistry

L. Chelico

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Author profile →

3 papers

Recent·Most cited

Divergence in dimerization and activity of primate APOBEC3C

A. Gaba, M. A. Hix, S. Suhail, B. Flath, B. Boysan, D. R. Williams, T. Pelletier, M. Emerman, F. Morcos, G. A. Cisneros, L. Chelico

This study identifies the molecular basis for differences in dimerization and antiviral activity of primate APOBEC3C proteins through biochemical, virological, and computational analyses.

bioRxiv · Jul 13, 2021Biochemistry

Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms

M. M. McDonnell, S. C. Karvonen, A. Gaba, B. Flath, L. Chelico, M. Emerman

This paper creates synthetic APOBEC3 proteins with enhanced antiviral activity against HIV-1 through non-catalytic mechanisms, comparable to the most potent natural APOBEC3 variant.

bioRxiv · Apr 6, 2021Microbiology

Induced mutagenesis by the DNA cytosine deaminase APOBEC3H Haplotype I protects against lung cancer

M. A. Hix, L. Wong, B. Flath, L. Chelico, G. A. Cisneros

The paper shows that a specific APOBEC3H Haplotype I mutation destabilizes the protein, reducing its mutagenic activity and protecting against lung cancer.

bioRxiv · Feb 28, 2020 · PreprintBiophysics