L. Chelico

Variability in HIV-1 Transmitted/Founder Virus Susceptibility to Combined APOBEC3F and APOBEC3G Host Restriction

This study investigates how APOBEC3F and APOBEC3G interact to resist HIV-1 Vif-mediated degradation and shows subtype-specific differences in Vif activity against these enzymes.

Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function

The paper identifies novel protein and RNA interactions of APOBEC3 enzymes, revealing deamination-independent roles in RNA biology and cancer.

Similar deamination activity but different phenotypic outcomes induced by APOBEC3 enzymes in breast epithelial cells

This study compares the mutagenic effects of APOBEC3A, APOBEC3B, and APOBEC3H in breast cells, finding similar DNA damage but distinct cancer-related phenotypes.

Divergence in dimerization and activity of primate APOBEC3C

This study identifies the molecular basis for differences in dimerization and antiviral activity of primate APOBEC3C proteins through biochemical, virological, and computational analyses.

Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms

This paper creates synthetic APOBEC3 proteins with enhanced antiviral activity against HIV-1 through non-catalytic mechanisms, comparable to the most potent natural APOBEC3 variant.

Species-specific differences in antagonism of APOBEC3 proteins by HIV-2 and SIVsmm Vif proteins

This study compares the ability of HIV-2 and SIVsmm Vif proteins to counteract human APOBEC3 proteins, showing HIV-2 acquired adaptive changes for efficient counteraction in humans.

Induced mutagenesis by the DNA cytosine deaminase APOBEC3H Haplotype I protects against lung cancer

The paper shows that a specific APOBEC3H Haplotype I mutation destabilizes the protein, reducing its mutagenic activity and protecting against lung cancer.