A. Gaba

Protein interaction map of APOBEC3 enzyme family reveals deamination-independent role in cellular function

The paper identifies novel protein and RNA interactions of APOBEC3 enzymes, revealing deamination-independent roles in RNA biology and cancer.

Variability in HIV-1 Transmitted/Founder Virus Susceptibility to Combined APOBEC3F and APOBEC3G Host Restriction

This study investigates how APOBEC3F and APOBEC3G interact to resist HIV-1 Vif-mediated degradation and shows subtype-specific differences in Vif activity against these enzymes.

Stable m7G Cap-Distal 5'UTR Hairpin Structure Mediates Distinct 40S and 60S Binding Dynamics

This study uses single-molecule fluorescence microscopy to show that stable 5'UTR hairpins reduce 60S recruitment and translation efficiency by destabilizing 40S-mRNA interactions.

m7G cap-eIF4E interaction stimulates polysome formation by enhancing first-round initiation kinetics

This study investigates how m7G cap-eIF4E interactions influence polysome formation kinetics using single-molecule tracking in wheat germ and HeLa extracts.

Divergence in dimerization and activity of primate APOBEC3C

This study identifies the molecular basis for differences in dimerization and antiviral activity of primate APOBEC3C proteins through biochemical, virological, and computational analyses.

Highly-potent, synthetic APOBEC3s restrict HIV-1 through deamination-independent mechanisms

This paper creates synthetic APOBEC3 proteins with enhanced antiviral activity against HIV-1 through non-catalytic mechanisms, comparable to the most potent natural APOBEC3 variant.

Species-specific differences in antagonism of APOBEC3 proteins by HIV-2 and SIVsmm Vif proteins

This study compares the ability of HIV-2 and SIVsmm Vif proteins to counteract human APOBEC3 proteins, showing HIV-2 acquired adaptive changes for efficient counteraction in humans.