BiophysicsbioRxiv
Functional and structural characterization of interactions between opposite subunits in HCN pacemaker channels
M. Kondapuram, B. Frieg, S. Yueksel…·J. Kusch
The paper identifies residue K464 in the C-linker of HCN2 channels as critical for stabilizing the closed state through interactions with opposite subunits, supported by mutagenesis, electrophysiology, and molecular dynamics simulations.
DOI 10.1038/s42003-022-03360-6