Author

B. Fromm

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 8 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 6 Research Focus:chromatin & epigenetic regulation· 6 Approach:statistical model· 6 Research Focus:cell type annotation· 4 Approach:experimental assay· 3 Organism:human· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2

Frequent Co-Authors

K. J. Peterson· 3 shared E. Hoye· 2 shared M. R. Friedlander· 2 shared T. Sorger· 2 shared A. A. Fretland· 1 shared A. Beavan· 1 shared A. Di Cosmo· 1 shared A. E. Jenike· 1 shared

Activity by Year

2017-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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3 shared papersEvolutionary Biology

K. J. Peterson

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Author profile →

10 papers

Recent·Most cited

Clockwork Orangutan: microRNAs, thermoregulatory tradeoffs, and models of brain size evolution.

T. Sorger, B. Fromm

This paper re-examines the Expensive Tissue Hypothesis, finding a thermoregulatory tradeoff between liver and brain proportions in mammals, and proposes a model of brain size evolution based on metabolic rates and microRNA families.

bioRxiv · May 21, 2024 · PreprintEvolutionary Biology

Rapid Adaption of Cellular Metabolic Rate to the microRNA Complements of Mammals and its Relevance to the Evolution of Endothermy

B. Fromm, T. Sorger

The paper develops a metric for cellular metabolic rate using microRNA family counts and shows its correlation with body temperature and evolutionary changes in mammals.

bioRxiv · Nov 24, 2022Evolutionary Biology

Direct observation of the evolution of cell-type specific microRNA expression signatures supports the hematopoietic origin model of endothelial cells

A. E. Jenike, K. M. Jenike, K. J. Peterson, B. Fromm, M. K. Halushka

The paper directly observes the evolution of a cell-type by tracking Mir-126 microRNA expression from proto-endothelial amoebocytes in tunicates to endothelial cells in vertebrates.

bioRxiv · Nov 23, 2022Cell Biology

The slow evolving genome of the xenacoelomorph worm Xenoturbella bocki

P. H. Schiffer, P. Natsidis, D. J. Leite, H. Robertson, F. Lapraz, F. Marletaz, B. Fromm, L. Baudry, F. Simpson, E. Hoye, A.-C. Zakrzewski, P. Kapli, K. J. Hoff, S. Mueller, M. Marbouty, , M. J. Telford

This study analyzes the genome of Xenoturbella bocki to assess its phylogenetic position and genomic complexity, finding it has a complex genome similar to other bilaterians.

bioRxiv · Jun 24, 2022 · PreprintEvolutionary Biology

MicroRNAs are deeply linked to the emergence of the complex octopus brain

G. Zolotarov, B. Fromm, I. Legnini, S. Ayoub, G. Polese, V. Maselli, P. J. Chabot, J. Vinther, R. Styfhals, E. Seuntjens, A. Di Cosmo, K. J. Peterson, N. Rajewsky

The paper profiles mRNAs and small RNAs in 18 octopus tissues, showing a massive expansion of miRNA genes in neuronal tissues and proposing miRNAs are linked to complex brain evolution.

bioRxiv · Feb 15, 2022Evolutionary Biology

microRNAs as Indicators into the Causes and Consequences of Whole Genome Duplication Events

K. J. Peterson, A. Beavan, P. Chabot, M. L. McPeek, D. Pisani, B. Fromm, O. Simakov

This study investigates the role of microRNAs in whole genome duplication events, finding that miRNA paralogues are functionally equivalent and that miRNA seed sequence diversity, not WGDs, correlates with morphological complexity.

bioRxiv · Sep 1, 2021Evolutionary Biology

A microRNA Signature of Metastatic Colorectal Cancer

E. Hoye, B. Fromm, P. H. M. Bottger, D. Domanska, A. T. Kristensen, C. Lund-Andersen, T. W. Abrahamsen, A. A. Fretland, V. J. Dagenborg, S. Lorenz, B. Edwin, E. Hovig, K. Flatmark

This study identifies a microRNA signature associated with metastatic progression in colorectal cancer using NGS data from 268 samples.

bioRxiv · Jun 1, 2020 · PreprintCancer Biology

Ancient microRNA profiles of a 14,300-year-old canid are taxonomically informative and give glimpses into gene regulation from the Pleistocene

B. Fromm, M. Tarbier, O. Smith, L. Dalen, T. M. Gilbert, M. R. Friedlander

The paper analyzes ancient microRNA profiles from a 14,300-year-old canid, showing they are taxonomically informative and provide insights into Pleistocene gene regulation.

bioRxiv · Dec 16, 2019Evolutionary Biology

Evolutionary implications of the microRNA- and piRNA complement of Lepidodermella squamata (Gastrotricha)

B. Fromm, J. P. Tosar, F. Aguilera, M. R. Friedlander, L. Bachmann, A. Hejnol

This study identifies miRNA and piRNA complements in Lepidodermella squamata, supporting a close evolutionary relationship between gastrotrichs and flatworms.

bioRxiv · Jan 4, 2019Evolutionary Biology

Extreme conservation of miRNA complements in Opisthorchiids

V. Ovchinnikov, V. A. Mordvinov, B. Fromm

The paper curates and reannotates miRNA complements of Opisthorchiid liver flukes, identifying conserved and species-specific miRNAs as potential biomarkers.

bioRxiv · Jun 6, 2017Evolutionary Biology