Primary oocytes with cellular senescence features are involved in ovarian aging in mice
H. Yan, E. A. Diaz Miranda, S. Jin, F. Wilson, K. An, B. Godbee, X. Zheng, A. R. Brau-Rodriguez, L. Lei
This study shows that senescent primary oocytes contribute to ovarian aging in mice, and their removal improves fertility and follicle numbers.
bioRxiv · Jan 8, 2024Cell Biology